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Peer Reviewed

Examining Cultural Similarities and Differences in Responses to Advice

UC Davis Previously Published Works (2013)

The present study compared and contrasted American and Chinese college students' responses to advice by examining the impact of perceived advice content features (response efficacy, feasibility, absence of limitations) and source characteristics (expertise, trustworthiness, liking) on recipient's evaluation of advice quality and intention to implement advice in each cultural group. American (N = 262) and Chinese college students (N = 319) completed questionnaires reporting on a recent instance of receiving advice with regard to a personal problem. Across both cultural groups, each of the perceived content and source features was positively associated with participants' evaluation of advice quality and intention to follow advice, and perceived content features had stronger and more direct influence on responses to advice than source characteristics did. Perceived content features had a stronger impact on Americans' intention to implement advice than they did for Chinese, whereas perceived source characteristics had a stronger impact on Chinese' intention to implement advice than they did for Americans. © The Author(s) 2011.

Cover page: Examining Cultural Similarities and Differences in Responses to Advice

Thesis
Peer Reviewed

Affine structure on the Teichmuller spaces and period maps for Calabi-Yau manifolds

Guan, Feng
Advisor(s): Guan, Feng

UCLA Electronic Theses and Dissertations (2014)

In this thesis, we prove that the Hodge metric completion of the Teichmuller space of polarized and marked Calabi-Yau manifolds is a complex affine manifold. As applications, we show that the extended period map from the completion space is injective into the period domain, that the completion space is a bounded domain of holomorphy and admits a complete Kahler-Einstein metric.

Cover page: Affine structure on the Teichmuller spaces and period maps for Calabi-Yau manifolds

Article
Peer Reviewed

Application of the Spin-Center Shift in Organic Synthesis

UCLA Previously Published Works (2022)

Spin-center shift (SCS) is a radical process involving 1,2-radical translocation along with a two-electron ionic movement, such as elimination of an adjacent leaving group. Such a process was initially observed in some important biochemical transformations, and the unique property has also attracted considerable interest in synthetic chemistry. Experimental, kinetic, as well as computational studies have been performed, and a series of useful radical transformations have been developed and applied in organic synthesis based on SCS processes in the last 20 years. This Perspective is an overview of radical transformations involving the SCS mechanism.

Cover page: Application of the Spin-Center Shift in Organic Synthesis

Article
Peer Reviewed

Gluon fragmentation to $^3D_J$ quarkonium and test of color-octet production mechanism

LBL Publications (1998)

We report the recent progress in the studies of D-wave heavy quarkonia production from gluon fragmentation at the Tevatron and in Z^0 decays, and the D-wave charmonia production in B decays. We show that the color-octet contributions are of crucial importance to the production of D-wave quarkonia. Signals, as strong as that for J/\psi and \psi^\prime, should be seen for the D-wave charmonium in the processes. These will provide a test of the color-octet production mechanism.

Cover page: Gluon fragmentation to $^3D_J$ quarkonium and test of color-octet production mechanism

Article
Peer Reviewed

DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol.

UC Riverside Previously Published Works (2022)

Thymidine glycol (Tg) is the most prevalent form of oxidatively induced pyrimidine lesions in DNA. Tg can arise from direct oxidation of thymidine in DNA. In addition, 5-methyl-2-deoxycytidine (5-mdC) can be oxidized to 5-mdC glycol, and its subsequent deamination also yields Tg. However, Tgs distribution in the human genome remains unknown. Here, we presented a DNA-protein cross-linking sequencing (DPC-Seq) method for genome-wide mapping of Tg in human cells. Our approach capitalizes on the specificity of a bifunctional DNA glycosylase, i.e., NTHL1, for the covalent labeling, as well as DPC pulldown, SDS-PAGE fractionation, and membrane transfer for highly efficient and selective enrichment of Tg-bearing DNA. By employing DPC-Seq, we detected thousands of Tg sites in the human genome, where dual ablation of NTHL1 and NEIL1, the major DNA glycosylases responsible for Tg repair, led to pronounced increases in the number of Tg peaks. In addition, Tg is depleted in genomic regions associated with active transcription but enriched at nucleosome-binding sites, especially at heterochromatin sites marked with H3K9me2. Collectively, we developed a DPC-Seq method for highly efficient enrichment of Tg-containing DNA and for genome-wide mapping of Tg in human cells. Our work offers a robust tool for future functional studies of Tg in DNA, and we envision that the method can also be adapted for mapping other modified nucleosides in genomic DNA in the future.

Cover page: DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol.

Article
Peer Reviewed

Ammonium Effects on Nitrate Uptake by Roots of Upland and Paddy Rice Seedlings Related to Transmembrane Potential Differences

The Proceedings of the International Plant Nutrition Colloquium XVI (2009)

Nitrate uptake characteristics and ammonium effects were compared between upland rice (Brazilian upland rice) and paddy rice (Wuyujing 3 and Yangdao 6) through the glass microelectrode technique and the concentration gradient method of uptake kinetics. Results indicated that nitrate uptake by rice seedlings and ammonium effects were related to transmembrane potential difference, and upland rice and paddy rice presented obviously different responses. Nitrate induced a rapid depolarization and then a slow repolarization of transmembrane potential in root epidermal cells, and even hyperpolarization was observed when nitrate concentration was low. Resting transmembrane potential of epidermal cells in Brazilian upland rice roots was lower and its response to NO3- was bigger than that of two paddy rice species. Depolarization of membrane potential was amplified when ammonium was simultaneously added with nitrate into the measure medium, but repolarization was reduced, even disappeared. Brazilian upland rice seedlings had high Vmax of nitrate uptake and low Km, furthermore, Vmax and Km were little affected by ammonium, but Vmax of Wuyujing 3 was reduced significantly. Therefore, inhibition of ammonium to nitrate uptake possibly due to decrease of membrane potential and influence of nitrate transporters. Moreover, inhibition of NH4+ differed obviously between upland rice and paddy rice.

Cover page: Ammonium Effects on Nitrate Uptake by Roots of Upland and Paddy Rice Seedlings Related to Transmembrane Potential Differences

Article
Peer Reviewed

Cost-effectiveness of skin biopsies performed by non-physician clinicians for Medicare beneficiaries

Dermatology Online Journal, Volume 27, Issue 6 (2021)

An increasing number of non-physician clinicians (NPCs) are providing dermatologic care. We compared the cost-effectiveness of skin biopsies performed by dermatologists and dermatology NPCs using publicly-available Medicare claims data and numbers needed to biopsy (NNBs) published in the literature. We estimated that dermatology NPCs performed slightly greater mean numbers of skin biopsies per beneficiary (0.51 versus 0.47) at a lower payment per biopsy ($44.93 versus $55.10) as compared to dermatologists. However, we estimated a higher mean cost per malignancy diagnosed by dermatology NPCs relative to dermatologists (range based on literature NNB values, $39.08 to $190.23). This translated to a $16.7M-$43.3M aggregate cost of additional, benign biopsies performed by NPCs on Medicare beneficiaries. Although this preliminary analysis has several limitations, including the reliance on NNB values for calculations, it likely highlights the importance of training, education, and supervision to promote diagnostic accuracy. Further investigation is needed so that the potential cost of additional skin biopsies performed by NPCs can be appropriately weighed against the improvement in dermatologic access by including NPCs in the dermatology workforce.