The superconducting critical temperature Tc of YBa2Cu3Ox single crystals (6.35 7) has been measured resistively as a function of pressure P (0P 20 kbar). The initial rate dTc/dP exhibits three distinct regimes, a narrow plateau near 7 with dTc/dP 0.04 K/kbar, a plateau in the range 6.4 6.8, where dTc/dP 0.43 K/kbar, and a maximum value 0.8 K/kbar at 6.35. An analysis of the Tc(x,P) data using a phenomenological model yields a pronounced peak near x=6.8 in dnh(x)/dP, where nh(x) is the change in the hole density in the CuO2 planes relative to the value corresponding to the fully oxygenated sample. © 1992 The American Physical Society.