home is a game about being alone. You explore your apartment and interact with the things and people around you. This game aims to show people a peek into my life in isolation and illustrate what can only happen once.

BACKGROUND: Institutions, departments, and individuals are increasingly facing challenges to determine how to enable their learners to acquire and curate rapidly changing knowledge and to foster the creation of lifelong learners in this information-rich digital era. METHODS: Much like the Precision Medicine initiative of 2015, in which diagnostic, treatment, and preventive care target individual patients based on their genetic and environmental profiles, educators can use the same principles to create a model of Precision Education. RESULTS: In this model, future facing individualizable educational infrastructure can consider innate qualities, learning style, behavior, environment, prior experience, expertise, and assessments. CONCLUSION: Educators can utilize Artificial Intelligence, the Master Adaptive Learner model, and key components of Competency Based Medical Education to transform the evolution of Health Professions Education to meet the individual and systemic needs of tomorrows learners, educators, and institutions to improve educational and clinical outcomes.

Cyanobacteria are a group of photosynthetic bacteria that play major roles in all major ecosystems and biogeochemical cycles. Cyanobacteria have also been shown to exhibit a remarkable morphological and metabolic diversity. All cyanobacteria also seem to exhibit the rare capacity to make hydrocarbons. The physiological or ecological function of these cyanobacterial hydrocarbons is currently unknown. Interest in finding sustainable sources of hydrocarbons could provide opportunities to replace petroleum derivatives like fuels, plastics and chemicals with sustainably derived molecules with identical properties. Cyanobacterial hydrocarbons are biosynthetically derived from fatty acids. There are two pathways that have recently been described to produce cyanobacterial hydrocarbons. One pathway involves fatty acyl ACP reductase and aldehyde deformylating oxygenase (FAAR/ADO) and is known to produce saturated alkanes one carbon shorter than their fatty acyl ACP substrates. The other is an olefin synthase (OLS) and is a polyketide synthase-type pathway involving elongation/decarboxylation mechanism that is known to produce terminal alkenes that are one carbon longer than their fatty acyl ACP substrate. The evolutionary history of these pathways is unknown. Additionally, the structural variability of the hydrocarbons derived from these pathways is relatively unexplored. This thesis investigates the structural variability, evolutionary history as well as novel biosynthetic pathway variability of cyanobacterial hydrocarbons. Chapter two presents evidence of the involvement of horizontal gene transfer in the evolutionary history of the two hydrocarbon pathways that were identified using a variety of bioinformatic analyses. An investigation of the structural diversity of cyanobacterial hydrocarbons as a consequence of the hydrocarbon pathway from which they are derived is presented in chapter three. Additionally, a variety of biosynthetic mechanisms are considered in the context of newly observed structural features including unique methylation and double bond positions. An effort to identify the methyltransferase responsible for branched hydrocarbon biosynthesis in Anabaena sp. PCC7120 is explored in chapter four. Finally, chapter five frames the major observations from the previous chapters in a broader context and discusses a wide variety of potential future directions for research on cyanobacterial hydrocarbon biosynthesis

HIV has long been associated with a number of inflammatory, infectious, and neoplastic skin conditions. In the era of anti-retroviral therapy, we have discovered even more about the relationship between skin disease and chronic immunosuppression. In particular, clinicians still face the propensity of persons living with HIV to develop difficult-to-control viral infections, chronic skin inflammation, and pruritus and-particularly as patients age-various types of skin cancers. Here, we summarize recent updates in the field of HIV dermatology and make recommendations to providers caring for these patients.