- Calabrese, Edward J;
- Bachmann, Kenneth A;
- Bailer, A John;
- Bolger, P Michael;
- Borak, Jonathan;
- Cai, Lu;
- Cedergreen, Nina;
- Cherian, M George;
- Chiueh, Chuang C;
- Clarkson, Thomas W;
- Cook, Ralph R;
- Diamond, David M;
- Doolittle, David J;
- Dorato, Michael A;
- Duke, Stephen O;
- Feinendegen, Ludwig;
- Gardner, Donald E;
- Hart, Ronald W;
- Hastings, Kenneth L;
- Hayes, A Wallace;
- Hoffmann, George R;
- Ives, John A;
- Jaworowski, Zbigniew;
- Johnson, Thomas E;
- Jonas, Wayne B;
- Kaminski, Norbert E;
- Keller, John G;
- Klaunig, James E;
- Knudsen, Thomas B;
- Kozumbo, Walter J;
- Lettieri, Teresa;
- Liu, Shu-Zheng;
- Maisseu, Andre;
- Maynard, Kenneth I;
- Masoro, Edward J;
- McClellan, Roger O;
- Mehendale, Harihara M;
- Mothersill, Carmel;
- Newlin, David B;
- Nigg, Herbert N;
- Oehme, Frederick W;
- Phalen, Robert F;
- Philbert, Martin A;
- Rattan, Suresh IS;
- Riviere, Jim E;
- Rodricks, Joseph;
- Sapolsky, Robert M;
- Scott, Bobby R;
- Seymour, Colin;
- Sinclair, David A;
- Smith-Sonneborn, Joan;
- Snow, Elizabeth T;
- Spear, Linda;
- Stevenson, Donald E;
- Thomas, Yolene;
- Tubiana, Maurice;
- Williams, Gary M;
- Mattson, Mark P
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.