This Letter to the Editor is a response to the author's paper, titled “Economic Evaluation of Ultrasound-guided Central Venous Catheter Confirmation vs Chest Radiography in Critically Ill Patients: A Labor Cost Model”. We agree that Point-Of-Care Ultrasound (POCUS) has been demonstrated to be a non-inferior assessment for confirmation of successful above the diaphragm Central Venous Catheter (CVC) placement when compared to Chest X-ray (CXR). From a cost analysis standpoint, we believe there are significant areas of direct and indirect costs that would demonstrate an advantage to the use of POCUS versus CXR.