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Open Access Publications from the University of California

Scholarly Works (8 results)

  • Article
  • Peer Reviewed
UCLA Previously Published Works (2010)
Abstract Background The waveform morphology of intracranial pressure pulses (ICP) is an essential indicator for monitoring, and forecasting critical intracranial and cerebrovascular pathophysiological variations. While current ICP pulse analysis frameworks offer satisfying results on most of the pulses, we observed that the performance of several of them deteriorates significantly on abnormal, or simply more challenging pulses. Methods This paper provides two contributions to this problem. First, it introduces MOCAIP++, a generic ICP pulse processing framework that generalizes MOCAIP (Morphological Clustering and Analysis of ICP Pulse). Its strength is to integrate several peak recognition methods to describe ICP morphology, and to exploit different ICP features to improve peak recognition. Second, it investigates the effect of incorporating, automatically identified, challenging pulses into the training set of peak recognition models. Results Experiments on a large dataset of ICP signals, as well as on a representative collection of sampled challenging ICP pulses, demonstrate that both contributions are complementary and significantly improve peak recognition performance in clinical conditions. Conclusion The proposed framework allows to extract more reliable statistics about the ICP waveform morphology on challenging pulses to investigate the predictive power of these pulses on the condition of the patient.
    Cover page: Robust Peak Recognition in Intracranial Pressure Signals
    • Article
    • Peer Reviewed
    UCLA Previously Published Works (2009)
    Following recent studies, the automatic analysis of intracranial pressure (ICP) pulses appears to be a promising tool for forecasting critical intracranial and cerebrovascular pathophysiological variations during the management of many disorders. A pulse analysis framework has been recently developed to automatically extract morphological features of ICP pulses. The algorithm is able to enhance the quality of ICP signals, to segment ICP pulses, and to designate the locations of the three ICP sub-peaks in a pulse. This paper extends this algorithm by utilizing machine learning techniques to replace Gaussian priors used in the peak designation process with more versatile regression models. The experimental evaluations are conducted on a database of ICP signals built from 700 h of recordings from 64 neurosurgical patients. A comparative analysis of different state-of-the-art regression analysis methods is conducted and the best approach is then compared to the original pulse analysis algorithm. The results demonstrate a significant improvement in terms of accuracy in favor of our regression-based recognition framework. It reaches an average peak designation accuracy of 99% using a kernel spectral regression against 93% for the original algorithm.
      Cover page: Regression analysis for peak designation in pulsatile pressure signals
      • Article
      • Peer Reviewed
      UCLA Previously Published Works (2019)
      The low cost, simple, noninvasive, and continuous measurement of cerebral blood flow velocity (CBFV) by transcranial Doppler is becoming a common clinical tool for the assessment of cerebral hemodynamics. CBFV monitoring can also help with noninvasive estimation of intracranial pressure and evaluation of mild traumatic brain injury. Reliable CBFV waveform analysis depends heavily on its accurate beat-to-beat delineation. However, CBFV is inherently contaminated with various types of noise/artifacts and has a wide range of possible pathological waveform morphologies. Thus, pulse onset detection is in general a challenging task for CBFV signal. In this paper, we conducted a comprehensive comparative analysis of three popular pulse onset detection methods using a large annotated dataset of 92,794 CBFV pulses-collected from 108 subarachnoid hemorrhage patients admitted to UCLA Medical Center. We compared these methods not only in terms of their accuracy and computational complexity, but also for their sensitivity to the selection of their parameters values. The results of this comprehensive study revealed that using optimal values of the parameters obtained from sensitivity analysis, one method can achieve the highest accuracy for CBFV pulse onset detection with true positive rate (TPR) of 97.06% and positive predictivity value (PPV) of 96.48%, when error threshold is set to just less than 10 ms. We conclude that the high accuracy and low computational complexity of this method (average running time of 4ms/pulse) makes it a reliable algorithm for CBFV pulse onset detection.
        Cover page: Identification of Pulse Onset on Cerebral Blood Flow Velocity Waveforms: A Comparative Study.
        • Article
        • Peer Reviewed
        Papers (2006)

        In this paper, we consider the analysis, implementation, and application of wideband sources using both seismic and acoustic sensors. We use the approximate maximum likelihood (AML) algorithm to perform acoustic direction of arrival (DOA). For non-uniform noise spectra, whitening filtering was applied to the received acoustic signals before the AML operation. For short-range seismic DOA applications, one method was based on eigen-decomposition of the covariance matrix and a second method was based on surface wave analysis. Two well-known optimization schemes were used to estimate the source locations from the estimated DOAs at sensors of known locations. Experimental estimation of the DOAs and resulting localizations using the acoustic and seismic signals generated by striking a heavy metal plate by a hammer were reported.

          Cover page: Analysis, Implementation, and Application of Acoustic and Seismic Arrays
          • Article
          • Peer Reviewed
          Papers (2004)

          Wireless sensor networks have been attracting increasing research interest given the recent advances in microelectronics, array processing, and wireless networking. Consisting of a large collection of small, wireless, low-cost, integrated sensing, computing, and communicating nodes capable of performing various demanding collaborative space-time processing tasks, wireless sensor network technology poses various unique design challenges, particularly for real-time operation. In this paper, we review the Approximate Maximum-Likelihood (AML) method for source localization and direction-of-arrival (DOA) estimations. Then, we consider the use of least-squares (LS) method applied to DOA bearing crossings to perform source localization. A novel virtual array model applicable to the AML-DOA estimation method is proposed for reverberant scenarios. Details on the wireless acoustical testbed are given. We consider the use of Compaq iPAQ 3760s, which are handheld, battery-powered device normally meant to be used as personal organizers (PDAs), as sensor nodes. The iPAQ provide a reasonable balance of cost, availability, and functionality. It has a build-in StrongARM processor, microphone, codec for acoustic acquisition and processing, and a PCMCIA bus for external IEEE 802.11b wireless cards for radio communication. The iPAQs form a distributed sensor network to perform real-time acoustical beamforming. Computational times and associated real-time processing tasks are described. Field measured results for linear, triangular, and square subarrays in free-space and reverberant scenarios are presented. These results show the effective and robust operation of the proposed algorithms and their implementations on a real-time acoustical wireless testbed.

            Cover page: Collaborative Sensor Networking Towards Real-Time Acoustical Beamforming in Free-Space and Limited Reverberence
            • Article
            • Peer Reviewed
            UCLA Previously Published Works (2019)
            Transcranial Doppler (TCD) ultrasound has been demonstrated to be a valuable tool for assessing cerebral hemodynamics via measurement of cerebral blood flow velocity (CBFV), with a number of established clinical indications. However, CBFV waveform analysis depends on reliable pulse onset detection, an inherently difficult task for CBFV signals acquired via TCD. We study the application of a new algorithm for CBFV pulse segmentation, which locates pulse onsets in a sequential manner using a moving difference filter and adaptive thresholding. The test data set used in this study consists of 92,012 annotated CBFV pulses, whose quality is representative of real world data. On this test set, the algorithm achieves a true positive rate of 99.998% (2 false negatives), positive predictive value of 99.998% (2 false positives), and mean temporal offset error of 6.10 ± 4.75 ms. We do note that in this context, the way in which true positives, false positives, and false negatives are defined caries some nuance, so care should be taken when drawing comparisons to other algorithms. Additionally, we find that 97.8% and 99.5% of onsets are detected within 10 and 30 ms, respectively, of the true onsets. The algorithms performance in spite of the large degree of variation in signal quality and waveform morphology present in the test data suggests that it may serve as a valuable tool for the accurate and reliable identification of CBFV pulse onsets in neurocritical care settings.
              Cover page: Algorithm for Reliable Detection of Pulse Onsets in Cerebral Blood Flow Velocity Signals.
              • Article
              Posters (2007)

              We present the use of the AML algorithm formulated for isotropic and non-isotrophic 3D acoustic source localization. Then we will discuss the recent efforts on the modifications of the wireless-linked acoustic sensing nodes, called ENSBoxes, to achieve accurate node self-localization and array orientations, all crucially needed for the accurate localization of acoustic source(s). We will summarize extensive field measured data collected at RMBL, Colorado, as well as at UCLA, to confirm the proper operations of the system.

                Cover page: 2D and 3D Acoustic Source Localization Using the AML Algorithm and ENSBox Nodes
                • Article
                • Peer Reviewed
                Papers (2005)

                Sensor network technology can revolutionize the study of animal ecology by providing a means of non-intrusive, simultaneous monitoring of interaction among multiple animals. In this paper, we investigate design, analysis, and testing of acoustic arrays for localizing acorn woodpeckers using their vocalizations. Each acoustic array consists of four microphones arranged in a square. All four audio channels within the same acoustic array are finely synchronized within a few micro seconds. We apply the approximate maximum likelihood (AML) method to synchronized audio channels of each acoustic array for estimating the direction-of-arrival (DOA) of woodpecker vocalizations. The woodpecker location is estimated by applying least square (LS) methods to DOA bearing crossings of multiple acoustic arrays. We have revealed the critical relation between microphone spacing of acoustic arrays and robustness of beamforming of woodpecker vocalizations. Woodpecker localization experiments using robust array element spacing in different types of environments are conducted and compared. Practical issues about calibration of acoustic array orientation are also discussed.

                  Cover page: Acoustic Sensor Networks for Woodpecker Localization
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