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Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment
- Georghiou, Sophia B;
- Rodwell, Timothy C;
- Korobitsyn, Alexei;
- Abbadi, Said H;
- Ajbani, Kanchan;
- Alffenaar, Jan-Willem;
- Alland, David;
- Alvarez, Nataly;
- Andres, Sönke;
- Ardizzoni, Elisa;
- Aubry, Alexandra;
- Baldan, Rossella;
- Ballif, Marie;
- Barilar, Ivan;
- Böttger, Erik C;
- Chakravorty, Soumitesh;
- Claxton, Pauline M;
- Cirillo, Daniela M;
- Comas, Iñaki;
- Coulter, Chris;
- Denkinger, Claudia M;
- Derendinger, Brigitta;
- Desmond, Edward P;
- de Steenwinkel, Jurriaan EM;
- Dheda, Keertan;
- Diacon, Andreas H;
- Dolinger, David L;
- Dooley, Kelly E;
- Egger, Matthias;
- Ehsani, Soudeh;
- Farhat, Maha R;
- Fattorini, Lanfranco;
- Finci, Iris;
- Le Ray, Laure Fournier;
- Furió, Victoria;
- Groenheit, Ramona;
- Gumbo, Tawanda;
- Heysell, Scott K;
- Hillemann, Doris;
- Hoffmann, Harald;
- Hsueh, Po-Ren;
- Hu, Yi;
- Huang, Hairong;
- Hussain, Alamdar;
- Ismail, Farzana;
- Izumi, Kiyohiko;
- Jagielski, Tomasz;
- Johnson, John L;
- Kambli, Priti;
- Kaniga, Koné;
- Karunaratne, GHR Eranga;
- Sharma, Meenu Kaushal;
- Keller, Peter M;
- Kelly, Ellis C;
- Kholina, Margarita;
- Kohli, Mikashmi;
- Kranzer, Katharina;
- Laurenson, Ian F;
- Limberis, Jason;
- Lin, S-Y Grace;
- Liu, Yongge;
- López-Gavín, Alexandre;
- Lyander, Anna;
- Machado, Diana;
- Martinez, Elena;
- Masood, Faisal;
- Mitarai, Satoshi;
- Mvelase, Nomonde R;
- Niemann, Stefan;
- Nikolayevskyy, Vladyslav;
- Maurer, Florian P;
- Merker, Matthias;
- Miotto, Paolo;
- Omar, Shaheed V;
- Otto-Knapp, Ralf;
- Palaci, Moisés;
- Gutiérrez, Juan José Palacios;
- Peacock, Sharon J;
- Peloquin, Charles A;
- Perera, Jennifer;
- Pierre-Audigier, Catherine;
- Pholwat, Suporn;
- Posey, James E;
- Prammananan, Therdsak;
- Rigouts, Leen;
- Robledo, Jaime;
- Rockwood, Neesha;
- Rodrigues, Camilla;
- Salfinger, Max;
- Schechter, Marcos C;
- Seifert, Marva;
- Sengstake, Sarah;
- Shinnick, Thomas;
- Shubladze, Natalia;
- Sintchenko, Vitali;
- Sirgel, Frederick;
- Somasundaram, Sulochana;
- Sterling, Timothy R;
- Spitaleri, Andrea;
- Streicher, Elizabeth;
- Supply, Philip;
- Svensson, Erik;
- Tagliani, Elisa;
- Tahseen, Sabira;
- Takaki, Akiko;
- Theron, Grant;
- Torrea, Gabriela;
- Van Deun, Armand;
- van Ingen, Jakko;
- Van Rie, Annelies;
- van Soolingen, Dick;
- Vargas, Roger;
- Venter, Amour;
- Veziris, Nicolas;
- Villellas, Cristina;
- Viveiros, Miguel;
- Warren, Robin;
- Wen, Shu'an;
- Werngren, Jim;
- Wilkinson, Robert J;
- Yang, Caie;
- Yılmaz, F Ferda;
- Zhang, Tingting;
- Zimenkov, Danila;
- Ismail, Nazir;
- Köser, Claudio U;
- Schön, Thomas
- et al.
Published Web Location
https://doi.org/10.1183/13993003.00166-2022Abstract
Inappropriately high breakpoints have resulted in systematic false-susceptible AST results to anti-TB drugs. MIC, PK/PD and clinical outcome data should be combined when setting breakpoints to minimise the emergence and spread of antimicrobial resistance. https://bit.ly/3i43wb6
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