Department of Cellular & Molecular Medicine - Open Access Policy Deposits

eScholarship stats: History by Item for December, 2024 through March, 2025

Item	Title	Total requests	2025-03	2025-02	2025-01	2024-12
0d951135	Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature.	165	8	8	149
9044v022	Brain organoids, consciousness, ethics and moral status	161	42	37	46	36
2bt9p0zz	The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis	149	26	41	46	36
70c3m48j	Spindle assembly checkpoint activation and silencing at kinetochores.	124	38	23	30	33
59b4x253	Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML	123	7	14	99	3
232927v1	SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2	117	29	28	30	30
8j35h8jn	Architecture and self‐assembly of the SARS‐CoV‐2 nucleocapsid protein	96	18	23	27	28
219597nn	Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis	95	25	24	22	24
85j9m77h	Control of bacterial immune signaling by a WYL domain transcription factor	93	20	23	26	24
1m706149	Reversing a model of Parkinson’s disease with in situ converted nigral neurons	87	15	19	30	23
0tt0x846	Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management	83	10	22	27	24
3710176w	Gap junctions: historical discoveries and new findings in the Caenorhabditis elegans nervous system	83	17	21	23	22
7b11m3h2	Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals	81	18	23	20	20
8s13b2f8	Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development	80	18	23	23	16
2231q4mb	Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration	79	16	27	16	20
404994bx	Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss	79	18	25	18	18
50w2z43f	Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer	79	24	25	17	13
0r65r9b9	Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells	75	9	21	24	21
3vq7746f	GIV/Girdin and Exo70 Collaboratively Regulate the Mammalian Polarized Exocytic Machinery	75	17	24	17	17
8jj6580k	Sialoglycan-binding patterns of bacterial AB<sub>5</sub> toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits.	75	17	18	19	21
9s9286nj	Identification of H3K4me1-associated proteins at mammalian enhancers	75	17	18	24	16
4rs831wx	Excitatory motor neurons are local oscillators for backward locomotion	71	18	19	11	23
1799t2f2	Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore.	65	3	3	59
2mf8p4v3	RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum.	65	17	19	13	16
44q19509	C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation	63	12	18	19	14
3pv76061	E-cigarettes compromise the gut barrier and trigger inflammation	55	16	15	12	12
5kd0v4kq	Large-scale tethered function assays identify factors that regulate mRNA stability and translation	50	11	16	12	11
0xm8q84f	Circular ecDNA promotes accessible chromatin and high oncogene expression	47	21	7	8	11
9b82739r	Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor	46	12	13	16	5
38q405h0	Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities	45	17	17	7	4
0853h6t4	DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages	44	12	14	18
1t76v633	Modeling colorectal cancers using multidimensional organoids	44	16	4	14	10
551458jj	APOE4/4 is linked to damaging lipid droplets in Alzheimers disease microglia.	44	5	27	7	5
1mf8f8xb	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens	43	27	6	8	2
1zt4w4dz	The Three-Dimensional Organization of Mammalian Genomes	43	20	12	8	3
4bc6c9wg	Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro	42	8	18	10	6
4qn8b3qf	Blocking Zika virus vertical transmission	42	22	9	8	3
0jb936p7	Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies.	41	13	17	5	6
2nz1949j	A large-scale binding and functional map of human RNA-binding proteins	41	15	6	15	5
6z9096mf	An in vivo neuroimmune organoid model to study human microglia phenotypes.	41	13	14	5	9
8077v518	Correction: Gene expression and chromatin conformation of microglia in virally suppressed people with HIV.	41	6	14	12	9
9v02c4c4	Control of cell proliferation by memories of mitosis.	39	12	8	7	12
08r3t35w	Tumour predisposition and cancer syndromes as models to study gene-environment interactions.	38	7	15	9	7
0bw638xs	Architecture and self-assembly of the jumbo bacteriophage nuclear shell	38	15	8	7	8
5s47j042	First Organoid Intelligence (OI) workshop to form an OI community	38	11	14	12	1
10q5b97w	RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression	37	12	9	12	4
36t6t6t8	A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome	37	9	14	10	4
4bd0d5ws	An environment-dependent transcriptional network specifies human microglia identity	37	7	12	11	7
8vf9p8g0	Diet-regulated production of PDGFcc by macrophages controls energy storage	37	9	9	13	6
8x30b7h0	Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation	37	8	9	11	9

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