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Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760323/No data is associated with this publication.
Abstract
Recent extraordinary advances in cancer immunotherapy rely primarily on marshaling T cell responses. Here we discuss how NK cell responses can be amplified. We find that MHC I-deficient tumors induce anergy of NK cells but that cytokine therapy restores NK cell activity and increases the survival of mice bearing MHC I-deficient tumors.
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