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Mitochondria Cripple without Krüppel
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https://doi.org/10.1016/j.tem.2015.08.004Abstract
Proper mitochondrial biogenesis and removal is crucial in maintaining a healthy heart. Liao et al now show key roles for cardiac KLF4 in mitochondrial homeostasis via its interaction with the ERR/PGC-1 module, and mitochondrial clearance via regulation of mitophagy. Disruption of KLF4 leads to profoundly injured mitochondria and cardiac failure.
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