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PINK1-Based Screen Shines Light on Autophagy Enhancers for Parkinson's Disease.
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845914/No data is associated with this publication.
Abstract
In this issue of Cell Chemical Biology, Zhang et al. (2017) report a zebrafish model of Parkinson's disease (PD), incorporating the PD-protein PINK1 and rotenone, a toxin linked to PD. Using it as a drug-screening platform, they identify trifluoperazine and other piperazine phenothiazines as protective compounds that enhance autophagy independent of PINK1.
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