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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models
Published Web Location
http://europepmc.org/articles/PMC3510335?pdf=renderNo data is associated with this publication.
Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease primarily affecting motor neurons. Mutations in the gene encoding TDP-43 cause some forms of the disease, and cytoplasmic TDP-43 aggregates accumulate in degenerating neurons of
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