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Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma – method-comparison evaluations
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259897/No data is associated with this publication.
Abstract
Unlabelled
Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals.Objective
To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals.Method
CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend portable analyzer were compared to those tested by a reference device (SYNCHRON LX 20).Results
The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%.Conclusions
These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a "false positive test", and should be confirmed by the reference device before concluding abnormality.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.