Intracortical recording devices have the capability to bring functionality back to people that have lost it through neurological conditions and injuries. These devices have been demonstrated in humans to control robotic limbs and enable brain-to-text communication. One major drawback of current intracortical recording technology is the limited effective recording lifetime of implant technology. To evaluate the lifetime of implants, durability studies are performed on implant designs. Current in vitro accelerated aging methods use heated saline baths intended to accelerate implant degradation using elevated temperatures and hydrogen peroxide to simulate the reactive oxygen attack that implants undergo as a part of the foreign body response. The focus of this thesis will be on the development of a microfluidic platform for durability evaluation of intracortical recording devices as well as a novel aging method that uses immune cells to simulate this reactive species attack. This work describes a microfluidic chamber design and fabrication process as well as techniques to control the reactive oxygen attack in the microreactor. The degradation of neural probes aged in microfluidic chambers using the saline/hydrogen peroxide method and the immune cell method is evaluated and compared to in vivo device degradation. An acceleration factor for immune cell aging is proposed for the acceleration of the reactive oxygen-induced polymer chain scission that occurs in vivo. Lastly, this work presents a model for implant lifetime prediction that incorporates both biological and material failure mechanisms using an equivalent circuit model for a neural implant.