- LaPorte, Matthew G;
- da Paz Lima, Dimas José;
- Zhang, Feng;
- Sen, Malabika;
- Grandis, Jennifer R;
- Camarco, Daniel;
- Hua, Yun;
- Johnston, Paul A;
- Lazo, John S;
- Resnick, Lynn O;
- Wipf, Peter;
- Huryn, Donna M
Synthesis and SAR investigation of 2-guanidinoquinazolines, initially identified in a high content screen for selective STAT3 pathway inhibitors, led to a more potent analog (11c) that demonstrated improved anti-proliferative activity against a panel of HNSCC cell lines.
