The main theme of this dissertation is the study of the lattice points in a rational convex polyhedron and their encoding in terms of Barvinok's short rational functions. The first part of this thesis looks into theoretical applications of these rational functions to Optimization, Statistics, and Computational Algebra. The main theorem on Chapter 2 concerns the computation of the \emph{toric ideal} $I_A$ of an integral $n \times d$ matrix $A$. We encode the binomials belonging to the toric ideal $I_A$ associated with $A$ using Barvinok's rational functions. If we fix $d$ and $n$, this representation allows us to compute a universal Gr\"obner basis and the reduced Gr\"obner basis of the ideal $I_A$, with respect to any term order, in polynomial time. We derive a polynomial time algorithm for normal form computations which replaces in this new encoding the usual reductions of the division algorithm. Chapter 3 presents three ways to use Barvinok's rational functions to solve Integer Programs. The second part of the thesis is experimental and consists mainly of the software package {\tt LattE}, the first implementation of Barvinok's algorithm. We report on experiments with families of well-known rational polytopes: multiway contingency tables, knapsack type problems, and rational polygons. We also developed a new algorithm, {\em the homogenized Barvinok's algorithm} to compute the generating function for a rational polytope. We showed that it runs in polynomial time in fixed dimension. With the homogenized Barvinok's algorithm, we obtained new combinatorial formulas: the generating function for the number of $5\times 5$ magic squares and the generating function for the number of $3\times 3 \times 3 \times 3$ magic cubes as rational functions.

We present a multivariate generating function for all n x n nonnegative integral matrices with all row and column sums equal to a positive integer t, the so called semi-magic squares. As a consequence we obtain formulas for all coefficients of the Ehrhart polynomial of the polytope B_n of n x n doubly-stochastic matrices, also known as the Birkhoff polytope. In particular we derive formulas for the volumes of B_n and any of its faces.

We encode the binomials belonging to the toric ideal $I_A$ associated with an integral $d \times n$ matrix $A$ using a short sum of rational functions as introduced by Barvinok \cite{bar,newbar}. Under the assumption that $d,n$ are fixed, this representation allows us to compute the Graver basis and the reduced Gr\"obner basis of the ideal $I_A$, with respect to any term order, in time polynomial in the size of the input. We also derive a polynomial time algorithm for normal form computation which replaces in this new encoding the usual reductions typical of the division algorithm. We describe other applications, such as the computation of Hilbert series of normal semigroup rings, and we indicate further connections to integer programming and statistics.