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Open Access Publications from the University of California

Scholarly Works (12 results)

  • Thesis
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UC Irvine Electronic Theses and Dissertations (2023)

The gaming landscape of Southeast Asia, dubbed by prominent market reports as “the world’s fastest growing games region,” has undergone profound transformation due to globalization since the late 1990s. Southeast Asia, however, remained an understudied region in game studies. Conversely, videogame as a medium is largely overlooked by scholars in Southeast Asian studies. Due to this gap, mainstream discourses about Southeast Asia vis-à-vis gaming are driven by industry rhetoric that frames the region as a new frontier to be exploited, neglecting the agency of Southeast Asians in shaping their own gaming culture and history.

To remedy this issue, this project charts the evolution of Southeast Asian gaming culture from the perspective of Malaysia and Singapore between the 1990s and 2010s occasioned by the region’s integration into the global gaming economy in ways that foreground the agency of local entities, including players, developers, private companies, and state agencies. In particular, the late 2000s is an important turning point which marks the intensification of endeavors to formalize gaming activities from within the region. The elevation of videogames into an essential cultural and economic sector within the region, while brought on by foreign impetus, is increasingly driven by Southeast Asian entities, especially state governments invested in strengthening their positions in the global digital economy.

This project proposes that Southeast Asia can serve as a framework to remap the globalization of videogames through the lens of regional integration, which allows for an alternative mode of knowledge production that recenters Southeast Asian autonomy. I name this framework the “Inter-Asian Gaming.” Inspired by Kuan-Hsing Chen’s “Asia as method,” Inter-Asian Gaming aims to decenter the West by focusing on regional gaming economy, including intra-regional cooperation within Southeast Asia and inter-regional exchanges with East Asia. I posit that a study of Southeast Asian gaming culture that centers on regional interconnections holds the potential to generate alternative understandings of non-Western gaming histories in relation to neighboring spaces instead of imperialist centers.

    Creative Commons 'BY-NC' version 4.0 license
    • Article
    • Peer Reviewed
    UC San Francisco Previously Published Works (2013)
    A novel point mutation resulting in a glutamate-to-glycine substitution in PRNP at codon 200, E200G with codon 129 MV polymorphism (cis valine) and type 2 PrPSc was identified in a patient with a prolonged disease course leading to pathology-proven Jakob-Creutzfeldt disease. Despite the same codon as the most common genetic form of human PRNP mutation, E200K, this novel mutation (E200G) presented with a different clinical and pathological phenotype, including prolonged duration, large vacuoles, no vacuolation in the hippocampus, severe neuronal loss in the thalamus, mild cerebellar involvement, and abundant punctate linear and curvilinear deposition of PrPSc in synaptic boutons and axonal terminals along the dendrites.
      Cover page: Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases
      • Article
      • Peer Reviewed
      UC San Francisco Previously Published Works (2014)

      Background and purpose

      In vivo MR imaging and postmortem neuropathologic studies have demonstrated elevated iron concentration and atrophy within the striatum of patients with Huntington disease, implicating neuronal loss and iron accumulation in the pathogenesis of this neurodegenerative disorder. We used 7T MR imaging to determine whether quantitative phase, a measurement that reflects both iron content and tissue microstructure, is altered in subjects with premanifest Huntington disease.

      Materials and methods

      Local field shift, calculated from 7T MR phase images, was quantified in 13 subjects with premanifest Huntington disease and 13 age- and sex-matched controls. All participants underwent 3T and 7T MR imaging, including volumetric T1 and 7T gradient recalled-echo sequences. Local field shift maps were created from 7T phase data and registered to caudate ROIs automatically parcellated from the 3T T1 images. Huntington disease-specific disease burden and neurocognitive and motor evaluations were also performed and compared with local field shift.

      Results

      Subjects with premanifest Huntington disease had smaller caudate volume and higher local field shift than controls. A significant correlation between these measurements was not detected, and prediction accuracy for disease state improved with inclusion of both variables. A positive correlation between local field shift and genetic disease burden was also found, and there was a trend toward significant correlations between local field shift and neurocognitive tests of working memory and executive function.

      Conclusions

      Subjects with premanifest Huntington disease exhibit differences in 7T MR imaging phase within the caudate nuclei that correlate with genetic disease burden and trend with neurocognitive assessments. Ultra-high-field MR imaging of quantitative phase may be a useful approach for monitoring neurodegeneration in premanifest Huntington disease.
        • Article
        • Peer Reviewed
        UC San Francisco Previously Published Works (2014)
        BACKGROUND AND PURPOSE: In vivo MR imaging and postmortem neuropathologic studies have demonstrated elevated iron concentration and atrophy within the striatum of patients with Huntington disease, implicating neuronal loss and iron accumulation in the pathogenesis of this neurodegenerative disorder. We used 7T MR imaging to determine whether quantitative phase, a measurement that reflects both iron content and tissue microstructure, is altered in subjects with premanifest Huntington disease. MATERIALS AND METHODS: Local field shift, calculated from 7T MR phase images, was quantified in 13 subjects with premanifest Huntington disease and 13 age- and sex-matched controls. All participants underwent 3T and 7T MR imaging, including volumetric T1 and 7T gradient recalled-echo sequences. Local field shift maps were created from 7T phase data and registered to caudate ROIs automatically parcellated from the 3T T1 images. Huntington disease-specific disease burden and neurocognitive and motor evaluations were also performed and compared with local field shift. RESULTS: Subjects with premanifest Huntington disease had smaller caudate volume and higher local field shift than controls. A significant correlation between these measurements was not detected, and prediction accuracy for disease state improved with inclusion of both variables. A positive correlation between local field shift and genetic disease burden was also found, and there was a trend toward significant correlations between local field shift and neurocognitive tests of working memory and executive function. CONCLUSIONS: Subjects with premanifest Huntington disease exhibit differences in 7T MR imaging phase within the caudate nuclei that correlate with genetic disease burden and trend with neurocognitive assessments. Ultra-high-field MR imaging of quantitative phase may be a useful approach for monitoring neurodegeneration in premanifest Huntington disease.
          Cover page: Quantitative 7T phase imaging in premanifest Huntington disease.
          • Article
          • Peer Reviewed
          UC Irvine Previously Published Works (1986)
          Adiabatic toroidal compression experiments were performed in conjunction with high power neutral beam injection in the Tokamak Fusion Test Reactor (TFTR). Acceleration of beam ions to energies nearly twice the injection energy was measured with a charge exchange neutral particle analyser. Measurements were also made of 2.5 MeV neutrons and 15 MeV protons produced in fusion reactions between the deuterium beam ions and the thermal deuterium and3He ions, respectively. When the plasma was compressed, the d(d, n)3He fusion reaction rate increased by a factor of five, and the3He(d, p) α rate by a factor of twenty. These data were simulated with a bounce averaged Fokker-Planck program, which assumed conservation of angular momentum and magnetic moment during compression. The results indicate that the beam ion acceleration was consistent with adiabatic scaling. © 1986 IOP Publishing Ltd.
            Cover page: Charge exchange and fusion reaction measurements during compression experiments with neutral beam heating in the Tokamak Fusion Test ReactorCreative Commons 'BY' version 4.0 license
            • Article
            • Peer Reviewed
            UC Irvine Previously Published Works (1996)
            A search for alpha driven beta-induced Alfvén eigenmodes (BAEs) was conducted in low current (1.0-1.6 MA) TFTR supershots. Stable high beta deuterium-tritium (DT) discharges were obtained with βp = 2.4 and a central alpha beta of 0.1%. Instabilities between 75 and 200 kHz were observed by magnetics probes in many DT discharges, but the activity was also present in deuterium-deuterium (DD) comparison discharges, indicating that these modes are not destabilized (principally) by the alpha particle population. Losses of fusion products are also similar in the two sets of discharges. Theoretical simulations confirm that the achieved alpha particle pressure is too small to produce instability.
              Cover page: Search for alpha driven BAEs in TFTRCreative Commons 'BY' version 4.0 license
              • Article
              • Peer Reviewed
              UC Irvine Previously Published Works (1996)
              Because alpha particle losses can have a significant influence on tokamak reactor viability, the loss of deuterium–tritium alpha particles from the Tokamak Fusion Test Reactor (TFTR) [K. M. McGuire et al., Phys. Plasmas 2, 2176 (1995)] has been measured under a wide range of conditions. In TFTR, first orbit loss and stochastic toroidal field ripple diffusion are always present. Other losses can arise due to magnetohydrodynamic instabilities or due to waves in the ion cyclotron range of frequencies. No alpha particle losses have yet been seen due to collective instabilities driven by alphas. Ion Bernstein waves can drive large losses of fast ions from TFTR, and details of those losses support one element of the alpha energy channeling scenario. © 1996, American Institute of Physics. All rights reserved.
                Cover page: Alpha particle losses from Tokamak Fusion Test Reactor deuterium–tritium plasmasCreative Commons 'BY' version 4.0 license
                • Article
                • Peer Reviewed
                UC Irvine Previously Published Works (2001)
                Significant progress in obtaining high performance discharges lasting many energy confinement times in the DIII-D tokamak has been realized in recent experimental campaigns. Normalized performance ∼10 has been sustained for more than 5>E with qmin > 1.5. (The normalized performance is measured by the product βNH89, indicating the proximity to the conventional β limits and energy confinement quality, respectively.) These H mode discharges have an ELMing edge and β < 5%. The limit to increasing β is a resistive wall mode, rather than the tearing modes as previously observed. Confinement remains good despite qmin > 1. The global parameters were chosen to optimize the potential for fully non-inductive current sustainment at high performance, which is a key program goal for the DIII-D facility. Measurement of the current density and loop voltage profiles indicate that ≈75% of the current in the present discharges is sustained non-inductively. The remaining ohmic current is localized near the half-radius. The electron cyclotron heating system is being upgraded to replace this remaining current with ECCD. Density and β control, which are essential for operating advanced tokamak discharges, were demonstrated in ELMing H mode discharges with βNH89 ≈ 7 for up to 6.3 s or ≈34τE. These discharges appear to have stationary current profiles with qmin ≈ 1.05 in agreement with the current profile relaxation time ≈1.8 s.
                  Cover page: Long pulse high performance discharges in the DIII-D tokamakCreative Commons 'BY' version 4.0 license
                  • Article
                  • Peer Reviewed
                  UC Irvine Previously Published Works (2000)
                  Advanced tokamaks seek to achieve a high bootstrap current fraction without sacrificing fusion power density or fusion gain. Good progress has been made towards the DIII-D research goal of demonstrating a high-β advanced tokamak plasma in steady state with a relaxed, fully non-inductive current profile and a bootstrap current fraction greater than 50%. The limiting factors for transport, stability, and current profile control in advanced operating modes are discussed in this paper.
                    Cover page: Advanced tokamak physics in DIII-DCreative Commons 'BY' version 4.0 license
                    • Article
                    • Peer Reviewed
                    UC Irvine Previously Published Works (1987)
                    Neutral-beam heating of plasmas in the Tokamak Fusion Test Reactor at low preinjection densities [ne(0)1019 m-3] were characterized by Te(0)=6.5 keV, Ti(0)=20 keV, ne(0)=7×1019 m-3, E=170 msec, theta=2, and a d(d,n)3He neutron emission rate of 1016 sec-1. The ion temperature and the deuterium-fusion neutron yields were significantly higher than for previous tokamak experiments. The low initial densities were achieved by operation of the Tokamak Fusion Test Reactor with low plasma currents (1 MA) and by extensive limiter conditioning. © 1987 The American Physical Society.
                      Cover page: High-temperature plasmas in a tokamak fusion test reactorCreative Commons 'BY' version 4.0 license
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