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Article
Peer Reviewed

Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Neogi, Ujjwal;
Rao, Shwetha D;
Bontell, Irene;
Verheyen, Jens;
Rao, Vasudev R;
Gore, Sagar C;
Soni, Neelesh;
Shet, Anita;
Schülter, Eugen;
Ekstrand, Maria L;
Wondwossen, Amogne;
Kaiser, Rolf;
Madhusudhan, Mallur S;
Prasad, Vinayaka R;
Sonnerborg, Anders

UC San Francisco Previously Published Works (2014)

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

Cover page: Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients