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Open Access Publications from the University of California

Scholarly Works (5 results)

  • Thesis
  • Peer Reviewed
UC Santa Barbara Electronic Theses and Dissertations (2015)

Quantum mechanics makes many predictions, such as superposition, projective measurement, and entanglement, which defy classical intuition. For many years it remained unclear if these predictions were real physical phenomena, or the result of an incomplete understanding of hidden classical variables. For quantum entanglement, the Bell inequality provided the first experimental bound on such hidden variable theories by considering correlated measurements between spatially separated photons. Following a similar logic, the Leggett-Garg inequality provides an experimental test of projective measurement by correlating sequential measurements of the same object. More recently, these inequalities have become important benchmarks for the ``quantumness'' of novel systems, measurement techniques, or methods of generating entanglement. In this work we describe a continuous and controlled exchange of extracted state information and two-qubit entanglement collapse, demonstrated using the hybrid Bell-Leggett-Garg inequality. This effect is quantified by correlating weak measurement results with subsequent projective readout to collect all the statistics of a Bell inequality experiment in a single quantum circuit. This result was made possible by technological advances in superconducting quantum processors which allow precise control and measurement in multi-qubit systems. Additionally we discuss the central role of superconducting Josephson parametric amplifiers, which are a requirement for high fidelity single shot qubit readout. We demonstrate the ability to measure average Bell state information with minimal entanglement collapse, by violating this hybrid Bell-Leggett-Garg inequality at the weakest measurement strengths. This result indicates that it is possible to learn about the dynamics of large entangled systems without significantly affecting their evolution.

    Cover page: Preserving entanglement during weak measurement demonstrated with a violation of the Bell-Leggett-Garg inequality
    • Article
    • Peer Reviewed
    UCLA Previously Published Works (2013)
    BACKGROUND: The antifungal posaconazole concentrates within host cells and protects against Aspergillus fumigatus. The specific subcellular location of posaconazole and the mechanism by which cell-associated posaconazole inhibits fungal growth remain uncharacterized. METHODS: Posaconazole was conjugated with the fluorophore boron-dipyrromethene (BDP-PCZ). A549 pulmonary epithelial cells and A. fumigatus were exposed to BDP-PCZ individually and in coculture. BDP-PCZ subcellular localization and trafficking were observed using confocal microscopy and flow cytometry. RESULTS: BDP-PCZ concentrated within A549 cell membranes, and in particular within the endoplasmic reticulum. Epithelial cell-associated BDP-PCZ rapidly transferred to and concentrated within A. fumigatus cell membranes on contact. BDP-PCZ transfer to conidia did not require phagocytosis and was markedly enhanced by the conidial hydrophobin RodA. Within AF, BDP-PCZ also concentrated in membranes including the endoplasmic reticulum and colocalized with the azole target enzyme CYP51a. Concentration of BDP-PCZ within host and fungal cell membranes persisted for >48 hours and could be competitively inhibited by posaconazole but not voriconazole. CONCLUSIONS: Posaconazole concentrates within host cell membranes and rapidly transfers to A. fumigatus, where it accumulates to high concentrations and persists at the site of its target enzyme. These intracellular and intercellular pharmacokinetic properties probably contribute to the efficacy of PCZ.
      Cover page: Pharmacokinetics of posaconazole within epithelial cells and fungi: insights into potential mechanisms of action during treatment and prophylaxis.
      • Article
      • Peer Reviewed
      UCLA Previously Published Works (2013)

      Background

      The antifungal posaconazole concentrates within host cells and protects against Aspergillus fumigatus. The specific subcellular location of posaconazole and the mechanism by which cell-associated posaconazole inhibits fungal growth remain uncharacterized.

      Methods

      Posaconazole was conjugated with the fluorophore boron-dipyrromethene (BDP-PCZ). A549 pulmonary epithelial cells and A. fumigatus were exposed to BDP-PCZ individually and in coculture. BDP-PCZ subcellular localization and trafficking were observed using confocal microscopy and flow cytometry.

      Results

      BDP-PCZ concentrated within A549 cell membranes, and in particular within the endoplasmic reticulum. Epithelial cell-associated BDP-PCZ rapidly transferred to and concentrated within A. fumigatus cell membranes on contact. BDP-PCZ transfer to conidia did not require phagocytosis and was markedly enhanced by the conidial hydrophobin RodA. Within AF, BDP-PCZ also concentrated in membranes including the endoplasmic reticulum and colocalized with the azole target enzyme CYP51a. Concentration of BDP-PCZ within host and fungal cell membranes persisted for >48 hours and could be competitively inhibited by posaconazole but not voriconazole.

      Conclusions

      Posaconazole concentrates within host cell membranes and rapidly transfers to A. fumigatus, where it accumulates to high concentrations and persists at the site of its target enzyme. These intracellular and intercellular pharmacokinetic properties probably contribute to the efficacy of PCZ.
        • Article
        • Peer Reviewed
        UC Riverside Previously Published Works (2022)
        Quantum many-body systems display rich phase structure in their low-temperature equilibrium states1. However, much of nature is not in thermal equilibrium. Remarkably, it was recently predicted that out-of-equilibrium systems can exhibit novel dynamical phases2-8 that may otherwise be forbidden by equilibrium thermodynamics, a paradigmatic example being the discrete time crystal (DTC)7,9-15. Concretely, dynamical phases can be defined in periodically driven many-body-localized (MBL) systems via the concept of eigenstate order7,16,17. In eigenstate-ordered MBL phases, the entire many-body spectrum exhibits quantum correlations and long-range order, with characteristic signatures in late-time dynamics from all initial states. It is, however, challenging to experimentally distinguish such stable phases from transient phenomena, or from regimes in which the dynamics of a few select states can mask typical behaviour. Here we implement tunable controlled-phase (CPHASE) gates on an array of superconducting qubits to experimentally observe an MBL-DTC and demonstrate its characteristic spatiotemporal response for generic initial states7,9,10. Our work employs a time-reversal protocol to quantify the impact of external decoherence, and leverages quantum typicality to circumvent the exponential cost of densely sampling the eigenspectrum. Furthermore, we locate the phase transition out of the DTC with an experimental finite-size analysis. These results establish a scalable approach to studying non-equilibrium phases of matter on quantum processors.
          Cover page: Time-crystalline eigenstate order on a quantum processor
          • Article
          • Peer Reviewed
          UC Riverside Previously Published Works (2021)
          Realizing the potential of quantum computing requires sufficiently low logical error rates1. Many applications call for error rates as low as 10-15 (refs. 2-9), but state-of-the-art quantum platforms typically have physical error rates near 10-3 (refs. 10-14). Quantum error correction15-17 promises to bridge this divide by distributing quantum logical information across many physical qubits in such a way that errors can be detected and corrected. Errors on the encoded logical qubit state can be exponentially suppressed as the number of physical qubits grows, provided that the physical error rates are below a certain threshold and stable over the course of a computation. Here we implement one-dimensional repetition codes embedded in a two-dimensional grid of superconducting qubits that demonstrate exponential suppression of bit-flip or phase-flip errors, reducing logical error per round more than 100-fold when increasing the number of qubits from 5 to 21. Crucially, this error suppression is stable over 50 rounds of error correction. We also introduce a method for analysing error correlations with high precision, allowing us to characterize error locality while performing quantum error correction. Finally, we perform error detection with a small logical qubit using the 2D surface code on the same device18,19 and show that the results from both one- and two-dimensional codes agree with numerical simulations that use a simple depolarizing error model. These experimental demonstrations provide a foundation for building a scalable fault-tolerant quantum computer with superconducting qubits.
            Cover page: Exponential suppression of bit or phase errors with cyclic error correction
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