When considering the location of objects and places, we often take perspectives in reference to ourselves or someone/something else. Using ourselves as a reference is considered using an egocentric reference frame, while using something external as a reference is considered using an allocentric reference frame. Of interest is the similarity of how these reference frames inform our understanding of both spatial and social cognitive processes. Similar to how we understand objects in relation to ourselves or an external reference, mentalizing and theory of mind processes have also been described using reference frames. Whether there is a common mechanism for using reference frames for processing both spatial and social information is unclear. The present study explored this idea with an online study where participants performed both a spatial and social (i.e., mentalizing) perspective taking task, along with questionnaire gauging personality, visualization ability, and anxiety. Participants who were better at taking someone else’s spatial perspective tended to be better at mentalizing. This relationship was not present when taking one’s own spatial perspective or when mentalizing was not necessary. We provide preliminary evidence that reference frames contribute to both spatial and social cognitive processes.