- Roose, Jeroen;
- Christensen, SM;
- Tu, HL;
- Jun, JE;
- Alvarez, S;
- Triplet, MG;
- Iwig, JS;
- Yadav, KK;
- Bar-Sagi, D;
- Roose, JP;
- Groves, JT
SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be initiated predominantly by membrane recruitment of SOS via the adaptor Grb2 and balanced by rapidly reversible Grb2-SOS binding kinetics. However, SOS has multiple
