Onsager reciprocity relations derive from the fundamental time reversibility of the underlying microscopic equations of motion. This gives rise to a large set of symmetric cross-coupling phenomena. We here demonstrate that different reciprocity relations may arise from the notion of mesoscopic time reversibility, i.e., reversibility of intrinsically coarse-grained equations of motion. We use Brownian dynamics as an example of such a dynamical description and show how it gives rise to reciprocity in the hydrodynamic dispersion tensor as long as the background flow velocity is reversed as well.