U.S. regulation of chemicals is in need of an overhaul, informed by European legislation and guided by new thinking about risk.

REACH represents a global paradigm shift in chemical regulation, and it has introduced a new, complex regulatory process to which chemical producers and users throughout supply chains must adapt. This paper presents results of survey research to illustrate whether and how the business members of a large Scandinavian trade organization understand and comply with REACH. It also explores how these businesses obtain information about the chemicals they use in their products, and whether they feel that the information they have is sufficient to meet their needs. In addition, the paper describes how business size affects these issues. The survey results show that, at the time of this study, many small and medium-sized enterprises (SMEs) and a number of larger firms were unaware of REACH. Survey results consistently showed that the size of a company is an important factor in both understanding of and compliance with REACH, with respondents from large firms having a better grasp of REACH and its implications than smaller companies. An effective implementation of REACH will require, at the most basic level, more attention to educating EU companies, especially smaller ones, on how and why REACH applies to them. Survey respondents who were aware of REACH and its applicability to their firms also reported the types of support they needed in order to better understand and comply with the regulation, with nearly 40% of all respondents expressing a need for help with data systems or tools to manage REACH requirements and communicate REACH requirements to suppliers and customers. Many companies reported needing more information from their suppliers on chemical composition and related health impacts of materials and products. Ensuring that this information is readily available throughout supply chains is essential to reducing the negative impacts of chemicals and products on human health and the environment.

More than 6600 coal-fired power plants serve an estimated five billion people globally and contribute 46% of annual CO₂ emissions. Gases and particulate matter from coal combustion are harmful to humans and often contain toxic trace metals. The decades-old Kosovo power stations, Europe's largest point source of air pollution, generate 98% of Kosovo's electricity and are due for replacement. Kosovo will rely on investment from external donors to replace these plants. Here, we examine non-CO₂ emissions and health impacts by using inductively coupled plasma mass spectrometry (ICP-MS) to analyze trace metal content in lignite coal from Obilic, Kosovo. We find significant trace metal content normalized per kWh of final electricity delivered (As (22.3 ± 1.7), Cr (44.1 ± 3.5), Hg (0.08 ± 0.010), and Ni (19.7 ± 1.7) mg/kWh_e). These metals pose health hazards that persist even with improved grid efficiency. We explore the air-pollution-related risk associated with several alternative energy development pathways. Our analysis estimates that Kosovo could avoid 2300 premature deaths by 2030 with investments in energy efficiency and solar PV backed up by natural gas. Energy policy decisions should account for all associated health risks, as should multilateral development banks before guaranteeing loans on new electricity projects.

Although the US government has made important improvements in chemical management since the 1970s, these advances have not kept pace with scientific knowledge about chemical hazards. While US federal chemical policy reform is being debated for the first time since 1976, some US businesses have voluntarily sought to improve their knowledge of chemical hazards in their supply chains, and several US states, the European Union, China, and other countries have moved forward with chemical policy reforms. Until policy reforms occur in the USA, the US chemical market will continue to experience problems associated with poor information on hazardous chemicals in supply chains. These market conditions make it difficult for consumer product companies to identify hazards and create safer products. Results from interviews with consumer product company representatives demonstrate that challenges in obtaining chemical-related information exist across sectors, and information on chemical hazards and uses can be conflicting, protected by trade secrets, lost in supply chains, or nonexistent. Interview results illustrate how some consumer product companies are exceeding regulatory requirements by voluntarily restricting from their products chemicals that could harm human health or the environment. Understanding the motivations behind—and barriers to—these actions could inform efforts to modernize US chemicals policies in ways that promote effective chemical management in supply chains. Using examples from the European Union and some US states, we introduce policy suggestions that would increase knowledge, market transparency, and information flows regarding hazardous chemicals and their uses; these would support the efforts of companies to develop and market safer products.

Consumer products are important sources of exposure to harmful chemicals. Product composition is often a mystery to users, however, due to gaps in the laws governing ingredient disclosure. A unique data set that the California Air Resources Board (CARB) uses to determine how volatile organic chemicals (VOCs) from consumer products affect smog formation holds a partial solution. By analyzing CARB data on VOCs in consumer products, we identified and quantified emissions of volatile chemicals regulated under the California Safe Drinking Water and Toxic Enforcement Act ("Prop 65"). We here highlight individual chemicals as well as consumer product categories that people are likely to be exposed to as individual consumers, in the workplace, and at the population level. Of the 33 Prop 65-listed chemicals that appear in the CARB emissions inventory, we classified 18 as "top tier priorities for elimination". Among these, methylene chloride and N-methyl-2-pyrrolidone were most prevalent in products across all three population groups. Of 172 consumer product categories, 105 contained Prop 65-listed chemicals. Although these chemicals are known carcinogens and reproductive/developmental toxicants, they remain in widespread use. Manufacturers and regulators should prioritize product categories containing Prop 65-listed chemicals for reformulation or redesign to reduce human exposures and associated health risks.

Background

The prevalence of toxic chemicals in US commerce has prompted some states to adopt laws to reduce exposure. One with broad reach is California's Proposition 65 (Prop 65), which established a list of chemicals that cause cancer, developmental harm, or reproductive toxicity. The law is intended to discourage businesses from using these chemicals and to minimize consumer exposure. However, a key question remains unanswered: Has Prop 65 reduced population-level exposure to the listed chemicals?

Objective

We used national biomonitoring data from the Centers for Disease Control and Prevention (CDC) to evaluate the impact of Prop 65 on population-level exposures.

Methods

We evaluated changes in blood and urine concentrations of 37 chemicals (including phthalates, phenols, VOCs, metals, PAHs, and PFAS), among US National Health and Nutrition Examination Survey (NHANES) participants in relation to the time of chemicals' Prop 65 listing. Of these, 11 were listed prior to, 11 during, and 4 after the biomonitoring period. The remaining 11 were not listed but were closely related to a Prop 65-listed chemical. Where biomonitoring data were available from before and after the date of Prop 65 listing, we estimated the change in concentrations over time for Californians compared with non-Californians, using a difference-in-differences model. We used quantile regression to estimate changes in exposure over time, as well as differences between Californians and non-Californians at the 25th, 75th, and 95th percentiles.

Results

We found that concentrations of biomonitored chemicals generally declined nationwide over time irrespective of their inclusion on the Prop 65 list. Median bisphenol A (BPA) concentrations decreased 15% after BPA's listing on Prop 65, whereas concentrations of the nonlisted but closely related bisphenol S (BPS) increased 20% over this same period, suggesting chemical substitution. Californians generally had lower levels of biomonitored chemicals than the rest of the US population.

Discussion

Our findings suggest that increased scientific and regulatory attention, as well as public awareness of the harms of Prop 65-listed chemicals, prompted changes in product formulations that reduced exposure to those chemicals nationwide. Trends in bisphenols and several phthalates suggest that manufacturers replaced some listed chemicals with closely related but unlisted chemicals, increasing exposure to the substitutes. Our findings have implications for the design of policies to reduce toxic exposures, biomonitoring programs to inform policy interventions, and future research into the regulatory and market forces that affect chemical exposure. https://doi.org/10.1289/EHP13956.