In the title compound, C(27)H(17)N(3)O(4), the azo group displays a trans conformation and the dihedral angles between the central benzene ring and the pendant anthracene and nitro-benzene rings are 82.94 (7) and 7.30 (9)°, respectively. In the crystal structure, weak C-H⋯O hydrogen bonds, likely associated with a dipole moment present on the mol-ecule, help to consolidate the packing.

The crystal structure of the title compound, C(31)H(26)N(4)O(4), displays a trans conformation for the nitro-phenyl-diazenyl portion of the mol-ecule. Packing diagrams indicate that weak C-H⋯O hydrogen bonds, likely associated with a strong dipole moment present in the mol-ecule, dictate the arrangement of mol-ecules in the crystal structure.

Development of calcium metal batteries has been historically frustrated by a lack of electrolytes capable of supporting reversible calcium electrodeposition. In this paper, we report the study of an electrolyte consisting of Ca(BH4)2 in tetrahydrofuran (THF) to gain important insight into the role of the liquid solvation environment in facilitating the reversible electrodeposition of this highly reactive, divalent metal. Through interrogation of the Ca2+ solvation environment and comparison with Mg2+ analogs, we show that an ability to reversibly electrodeposit metal at reasonable rates is strongly regulated by dication charge density and polarizability. Our results indicate that the greater polarizability of Ca2+ over Mg2+ confers greater configurational flexibility, enabling ionic cluster formation via neutral multimer intermediates. Increased concentration of the proposed electroactive species, CaBH4+, enables rapid and stable delivery of Ca2+ to the electrode interface. This work helps set the stage for future progress in the development of electrolytes for calcium and other divalent metal batteries.

Multitarget-directed ligands are a promising class of drugs for discovering innovative new therapies for difficult to treat diseases. In this study, we designed dual inhibitors targeting the human fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme. Targeting both of these enzymes concurrently with single target inhibitors synergistically reduces inflammatory and neuropathic pain; thus, dual FAAH/sEH inhibitors are likely to be powerful analgesics. Here, we identified the piperidinyl-sulfonamide moiety as a common pharmacophore and optimized several inhibitors to have excellent inhibition profiles on both targeted enzymes simultaneously. In addition, several inhibitors show good predicted pharmacokinetic properties. These results suggest that this series of inhibitors has the potential to be further developed as new lead candidates and therapeutics in pain management.