Addressing the global challenges of desertification, land degradation, and drought (DLDD), and their impacts on achieving sustainable development goals for coupled human-environmental systems is a key component of the 2030 Agenda for Sustainable Development. In particular, Sustainable Development Goal (SDG) 15.3 aims to, “by 2030, combat desertification, restore degraded land and soil, including land affected by desertification, drought and floods, and strive to achieve a land degradation-neutral world”. Addressing this challenge is essential for improving the livelihoods of those most affected by DLDD and for safeguarding against the most extreme effects of climate change. This paper introduces a conceptual framework for improved monitoring of DLDD in the context of United Nations Convention to Combat Desertification (UNCCD) Strategic Objective 2 (SO2) and its expected impacts: food security and adequate access to water for people in affected areas are improved; the livelihoods of people in affected areas are improved and diversified; local people, especially women and youth, are empowered and participate in decision-making processes in combating DLDD; and migration forced by desertification and land degradation is substantially reduced. While it is critical to develop methods and tools for assessing DLDD, work is needed first to provide a conceptual roadmap of the human dimensions of vulnerability in relation to DLDD, especially when attempting to create a globally standardized monitoring approach.