As online shopping nears its third decade, it is clear that its impacts on urban goods flow are profound. Increased freight traffic and related negative externalities such as greenhouse gas emissions and local air pollution can impede sustainability goals. In response, e-retailers are exploring innovative distribution strategies to enhance last-mile delivery sustainability and efficiency. They use urban consolidation centers with light-duty vehicles like electric vans and cargo bikes, establish alternative customer pickup points, and deploy crowdsourced delivery networks. Advanced technologies that may streamline deliveries, such as autonomous delivery robots and unmanned aerial vehicles, are being tested. University of California Davis and Irvine researchers have investigated these strategies under economic viability, environmental efficiency, and social equity frameworks. Different modeling approaches were implemented to evaluate last-mile network designs and the potential for decarbonizing delivery fleets by switching to electric vehicles. Key findings suggest that while these innovative strategies offer substantial environmental benefits and reduce operational costs, they also present challenges like higher initial investments and operational hurdles. The study emphasizes the need for ongoing innovation and careful strategy implementation to balance sustainability with urban delivery systems’ economic and service reliability demands.