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Scholarly Works (1 results)

Article
Peer Reviewed

Targeted Molecular Imaging of Cancer Cells Using MS2-Based 129Xe NMR

Jeong, Keunhong;
Netirojjanakul, Chawita;
Munch, Henrik K;
Sun, Jinny;
Finbloom, Joel A;
Wemmer, David E;
Pines, Alexander;
Francis, Matthew B

UC Berkeley Previously Published Works (2016)

We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.