Research has shown that negative effects of stress on undergraduate students can have a significant impact on their college experience. Most of what we know about this topic is quantitative, based on surveys that provide self-reported information for large numbers of college students. The present study provides an in-depth qualitative perspective on college students and stress that foregrounds the voices of these emerging adults. Specifically, in this article we (a) share findings from a study using qualitative methods to examine how college students experience and manage stress and (b) provide strategies to help anthropology instructors design and manage their classes to improve learning for students under chronic stress.