AbstractObjectives: This applied project was undertaken to create and examine the acceptability of an evidence-based educational module in the adult medical surgical units of an academic medical center. Methods: A multimedia education module focused on venous access device selection factors and indications/contraindications using practice guidelines from the Vessel Health and Preservation (VHP) framework. The module interface was designed and developed using an animated video creation platform called Vyond so that nurses could complete the training in approximately 20 minutes at a time of their choosing. The video was accessible to any device with an internet connection and was posted on a variety of video-hosting sites. After completing the educational module, an on-line questionnaire assessing participants’ characteristics, knowledge and satisfaction was self-administered using the Qualtrics platform. The links to the video and survey were shared with participants via email. Descriptive statistics were used to summarize participants’ characteristics, post-assessment quiz scores, and satisfaction ratings about the animated educational module. Results: Seventy-seven percent of 26 potential project participants responded to the survey (n=20). More than half of the respondents (n=11) completed a previous training related to the topic. All participants achieved 100% correct responses to the six post-knowledge assessment questions and favorably rated their satisfaction with the multimedia educational module. Conclusion: The applied project demonstrated the potential for introducing an animated multimedia technology to meet the nurses’ education needs in the acute setting. Developing a concise, innovative, and engaging educational module could result in positive learning outcomes. Further investigation is needed to examine the acceptability of an animated multimedia educational module in other patient care areas such as critical, emergency or pediatric care, as well as ordering providers, pre-licensure nursing students and emerging clinicians.