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Scholarly Works (1 results)

Article
Peer Reviewed

Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

Weiner, Michael;
Rajagopalan, P;
Jahanshad, N;
Stein, JL;
Hua, X;
Madsen, SK;
Kohannim, O;
Hibar, DP;
Toga, AW;
Jack, CR;
Saykin, AJ

UC San Francisco Previously Published Works (2012)

A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people