Vibrio Cholerae is considered an important human pathogen causing worldwide health problem and commonly exists in aquatic reservoirs. Photoinactivation of 405 nm light and photothermal disinfection by near infrared lasers have been investigated on various types of bacterial species with a notably high killing efficien. This work combines the photoinactivation of 405 nm light with plasmonic enhanced photothermal effect on the surface of an Al nanoantenna disk array. A significant cell reduction of Vibrio Cholerae was found after 20 min illumination with almost 99.99% of bacteria inactivated which suggests potential use for clinical and medical applications.