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Open Access Publications from the University of California

Scholarly Works (18 results)

  • Article
  • Peer Reviewed
UC San Francisco Previously Published Works (2010)
Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering showed three reproducible LMS clusters. Array comparative genomic hybridization (aCGH) was performed on 20 LMS samples and showed that the molecular subtypes defined by gene expression showed distinct genomic changes. Tumors from the 'muscle-enriched' cluster showed significantly increased copy number changes (P=0.04). A majority of the muscle-enriched cases showed loss at 16q24, which contains Fanconi anemia, complementation group A, known to have an important role in DNA repair, and loss at 1p36, which contains PRDM16, of which loss promotes muscle differentiation. Immunohistochemistry (IHC) was performed on LMS tissue microarrays (n=377) for five markers with high levels of messenger RNA in the muscle-enriched cluster (ACTG2, CASQ2, SLMAP, CFL2 and MYLK) and showed significantly correlated expression of the five proteins (all pairwise P<0.005). Expression of the five markers was associated with improved disease-specific survival in a multivariate Cox regression analysis (P<0.04). In this analysis that combined gene expression profiling, aCGH and IHC, we characterized distinct molecular LMS subtypes, provided insight into their pathogenesis, and identified prognostic biomarkers.
    Cover page: Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling
    • Article
    LBL Publications (2007)
    Measurements of two-particle correlations on transverse momentum pt for Au-Au collisions at sqrt sNN = 130 GeV are presented. Significant large-momentum-scale correlations are observed for charged primary hadrons with 0.15 <_ pt <_ 2 GeV/c and pseudorapidity lbar eta rbar <_ 1.3. Such correlations were not observed in a similar study at lower energy and are not predicted by theoretical collision models. Their direct relation to mean-pt fluctuations measured in the same angular acceptance is demonstrated. Positive correlations are observed for pairs of particles which have large pt values while negative correlations occur for pairs in which one particle has large pt and the other has much lower pt. The correlation amplitudes per final state particle increase with collision centrality. The 3 observed correlations are consistent with a scenario in which the transverse momentum of hadrons
      Cover page: Two-Particle Correlations on Transverse Momentum and Momentum Dissipation in Au-Au Collisions at sqrt sNN = 130 GeV
      • Article
      LBL Publications (2008)

      We present the first statistically meaningful results from two-K0s interferometry in heavy-ion collisions. A model that takes the effect of the strong interaction into account has been used to fit the measured correlation function. The effects of single and coupled channel were explored. At the mean transverse mass m_T = 1.07 GeV, we obtain the values R = 4.09 +- 0.46 (stat.) +- 0.31 (sys) fm and lambda = 0.92 +- 0.23 (stat) +- 0.13 (sys), where R and lambda are the invariant radius and chaoticity parameters respectively. The results are qualitatively consistent with m_T systematics established with pions in a scenario characterized by a strong collective flow.

        Cover page: Neutral Kaon Interferometry in Au+Au collisions at sqrt(s_NN) = 200 GeV
        • Article
        LBL Publications (2008)
          Cover page: Spin alignment measurements of the K*0(892) and phi(1020) vector mesons in heavy ion collisions at sqrt sNN = 200 GeV
          • Article
          LBL Publications (2007)
          We report the measurement of Gamma and Gamma bar yields and inverse slope parameters in d+Au collisions at sqrt sNN = 200 GeV at forward and backward rapidities (y = +-2.75), using data from the STAR forward time projection chambers. The contributions of different processes to baryon transport and particle production are probed exploiting the inherent asymmetry of the d+Au system. Comparisons to model calculations show that baryon transport on the deuteron side is consistent with multiple collisions of the deuteron nucleons with gold participants. On the gold side, HIJING-based models without a hadronic rescattering phase do not describe themeasured particle yields, while models that include target remnants or hadronic rescattering do. The multichain model can provide a good description of the net baryon density in d+Au collisions at energies currently available at the BNL Relativistic Heavy Ion Collider, and the derived parameters of the model agree with those from nuclear collisions at lower energies.
            Cover page: Forward Lambda Production and Nuclear Stopping Power in d + Au Collisions at sqrt sNN = 200 GeV
            • Article
            LBL Publications (2008)
              Cover page: Centrality dependence of charged hadron and strange hadron elliptic flow from sqrt sNN = 200 GeV Au + Au collisions
              • Article
              • Peer Reviewed
              UCLA Previously Published Works (2006)
              We present the first statistically meaningful results from two-Ks0 interferometry in heavy-ion collisions at sNN=200 GeV. A model that takes the effect of the strong interaction into account has been used to fit the measured correlation function. The effects of single and coupled channels were explored. At the mean transverse mass mT =1.07 GeV, we obtain the values R=4.09±0.46(stat)±0.31(sys) fm and λ=0.92±0.23(stat) ±0.13(sys), where R and λ are the invariant radius and chaoticity parameters, respectively. The results are qualitatively consistent with mT systematics established with pions in a scenario characterized by a strong collective flow. © 2006 The American Physical Society.
                Cover page: Neutral kaon interferometry in Au+Au collisions at sNN=200 GeV
                • Article
                Lawrence Berkeley National Laboratory (2008)

                We report a measurement of the longitudinal double-spin asymmetry A_LL and the differential cross section for inclusive midrapidity jet production in polarized proton collisions at sqrt(s)=200 GeV. The cross section data cover transverse momenta 5 < pT < 50 GeV/c and agree with next-to-leading order perturbative QCD evaluations. The A_LL data cover 5 < pT < 17 GeV/c and disfavor at 98 percent C.L. maximal positive gluon polarization in the polarized nucleon.

                  Cover page: Longitudinal double-spin asymmetry and cross section for inclusive jet production in polarized proton collisions at sqrt(s) = 200 GeV
                  • Article
                  Lawrence Berkeley National Laboratory (2008)

                  We report the first measurement of the opening angle distribution between pairs of jets produced in high-energy collisions of transversely polarized protons. The measurement probes (Sivers) correlations between the transverse spin orientation of a proton and the transverse momentum directions of its partons. With both beams polarized, the wide pseudorapidity (-1 leq eta leq +2) coverage for jets permits separation of Sivers functions for the valence and sea regions. The resulting asymmetries are all consistent with zero and considerably smaller than Sivers effects observed in semi-inclusive deep inelastic scattering (SIDIS). We discuss theoretical attempts to reconcile the new results with the sizable transverse spin effects seen in SIDIS and forward hadron production in pp collisions.

                    Cover page: Measurement of Transverse Single-Spin Asymmetries for Di-Jet Production in Proton-Proton Collisions at sqrt s = 200 GeV
                    • Article
                    • Peer Reviewed
                    UCLA Previously Published Works (2008)
                    We present the first measurements of the ρ(770)0,K*(892), Δ(1232)++,Σ(1385), and Λ(1520) resonances in d+Au collisions at sNN=200 GeV, reconstructed via their hadronic decay channels using the STAR detector (the solenoidal tracker at the BNL Relativistic Heavy Ion Collider). The masses and widths of these resonances are studied as a function of transverse momentum pT. We observe that the resonance spectra follow a generalized scaling law with the transverse mass mT. The pT of resonances in minimum bias collisions are compared with the pT of π,K, and p̄. The ρ0/π-,K*/K-,Δ++/p,Σ(1385)/Λ, and Λ(1520)/Λ ratios in d+Au collisions are compared with the measurements in minimum bias p+p interactions, where we observe that both measurements are comparable. The nuclear modification factors (RdAu) of the ρ0,K*, and Σ* scale with the number of binary collisions (Nbin) for pT 1.2 GeV/c. © 2008 The American Physical Society.
                      Cover page: Hadronic resonance production in d+Au collisions at sNN=200 GeV measured at the BNL Relativistic Heavy Ion Collider
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