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Article
Peer Reviewed

Using time‐weighted average change from baseline of SARS‐CoV‐2 viral load to assess impact of hydroxychloroquine as postexposure prophylaxis and early treatment for COVID‐19

Kumbhakar, Raaka;
Neradilek, Moni;
Barnabas, Ruanne V;
Stewart, Jenell;
Karita, Helen C Stankiewicz;
Landovitz, Raphael J;
Kissinger, Patricia J;
Jerome, Keith R;
Paasche‐Orlow, Michael K;
Bershteyn, Anna;
Chu, Helen Y;
Neuzil, Kathleen M;
Greninger, Alexander L;
Luk, Alfred;
Wald, Anna;
Brown, Elizabeth R;
Johnston, Christine

UCLA Previously Published Works (2022)

Two randomized controlled trials demonstrated no clinical benefit of hydroxychloroquine (HCQ) for either postexposure prophylaxis or early treatment of SARS-CoV-2 infection. Using data from these studies, we calculated the time-weighted average change from baseline SARS-CoV-2 viral load and demonstrated that HCQ did not affect viral clearance.

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