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Article
Peer Reviewed

Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus

UC San Francisco Previously Published Works (2013)

Diseases such as type 2 diabetes (T2D) result from environmental and genetic factors, and risk varies considerably in the population. T2D-related genetic loci discovered to date explain only a small portion of the T2D heritability. Some heritability may be

Article
Peer Reviewed

Ethnic differences in the relationship between insulin sensitivity and insulin response: A systematic review and meta-analysis

UC San Francisco Previously Published Works (2013)

OBJECTIVE - Human blood glucose levels have likely evolved toward their current point of stability over hundreds of thousands of years. The robust population stability of this trait is called canalization. It has been represented by a hyperbolic function o

Article
Peer Reviewed

Anti-CD44 antibody treatment lowers hyperglycemia and improves insulin resistance, adipose inflammation, and hepatic steatosis in diet-induced obese mice.

UC San Francisco Previously Published Works (2015)

Type 2 diabetes (T2D) is a metabolic disease affecting >370 million people worldwide. It is characterized by obesity-induced insulin resistance, and growing evidence has indicated that this causative link between obesity and insulin resistance is associate