Reappraisal (reconstruing emotional experiences to alter their impact) and suppression (inhibiting emotionally expressive behavior) are emotion-regulation strategies with important implications for depression. While reappraisal generally predicts lower depressive symptoms, suppression generally predicts higher depressive symptoms. Because cultural factors can influence the processes involved in these links and because adolescence-especially for ethnic minority youth-brings particular emotional challenges, it's critical to investigate these links among Mexican-origin adolescents. However, research examining emotion regulation among Mexican-origin individuals is scarce and generally limited to cross-sectional designs. Thus, we examined prospective associations between reappraisal and suppression (assessed at age 17) and 2 facets of depressive symptoms (anhedonia and general distress) over 3 years (assessed at ages 16, 18, and 19) among 228 Mexican-origin adolescents. Latent growth curve models indicated that reappraisal was associated with lower anhedonia at baseline (age 16) and lower anhedonia over time, whereas suppression predicted greater anhedonia at baseline but not change over time. Consistent with the Mexican cultural value of simpatía, which emphasizes expressing positive emotions and inhibiting negative emotions, suppression of positive emotions was associated with greater anhedonia over time whereas suppression of negative emotions was associated with lower anhedonia over time. However, neither associated with anhedonia at baseline. Reappraisal and suppression were not associated with distress symptoms, and no effects were moderated by familism, household income, gender, or child nativity. The anhedonia results suggest that the benefits of reappraisal extend to Mexican-origin adolescents, but the effects of suppression may depend upon emotional valence in this group. (PsycInfo Database Record (c) 2022 APA, all rights reserved).