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Scholarly Works (1 results)

Article
Peer Reviewed

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.

Wilson, David;
Abbotts, R;
Jewell, R;
Nsengimana, J;
Maloney, DJ;
Simeonov, A;
Seedhouse, C;
Elliott, F;
Laye, J;
Walker, C;
Jadhav, A

UC San Francisco Previously Published Works (2014)

Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer. We have developed small molecule inhibitors against APE1 repair nuclease activi