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Scholarly Works (2 results)

Article
Peer Reviewed

MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer

Goga, Andrei;
Willenbring, Holger;
Lim, L;
Balakrishnan, A;
Huskey, N;
Jones, KD;
Jodari, M;
Ng, R;
Song, G;
Riordan, J;
Anderton, B;
Cheung, ST

UC San Francisco Previously Published Works (2014)

© 2013 Authors.Hepatocellular carcinoma (HCC) is associated with poor survival for patients and few effective treatment options, raising the need for novel therapeutic strategies. MicroRNAs (miRNAs) play important roles in tumor development and show deregu

Article
Peer Reviewed

CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation

Hebrok, Matthias;
Goga, Andrei;
Oakes, Scott;
Blelloch, Robert;
Huskey, N;
Guo, T;
Evason, K;
Momcilovic, O;
Pardo, D;
Creasman, K;
Judson, R

UC San Francisco Previously Published Works (2014)

Embryonic stem cells (ESCs) have adopted an accelerated cell-cycle program with shortened gap phases and precocious expression of cell-cycle regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs). We examined the effect of CDK inhibitio