While the impact of social cognition on novel word learning has been extensively studied in monolingual populations, limited research has investigated its role in multilingual children with and without autism spectrum disorder. This study examined the role of multilingualism on the acquisition of novel English words under directly addressed and overhearing conditions. Participants included four groups of children with different language status (multilingual and monolingual and diagnostic status (typically developing and autistic). The results revealed that the learning preferences vary across participant groups depending on their language and diagnostic statuses. Additionally, dynamic patterns of novel word learning were unveiled, demonstrating the influence of English vocabulary proficiency on multilingual children's learning process. The findings highlighted the complex role of multilingualism on driving the formation of learning preference for typical developing and autistic children.