The most common infectious etiologies of vaginitis include Gardnerella bacterial vaginosis, candidiasis, and trichomoniasis. A few case reports describe symptomatic infection with Neisseria (N) meningitidis, an organism with potential for causing systemic disease with a high rate of morbidity and mortality. We describe a patient who presented with fulminant meningitis secondary to symptomatic vaginitis in which N. meningitidis was cultured. Due to the potential for significant morbidity and mortality as demonstrated by this case report, knowledge of this entity may prompt physicians to aggressively treat patients with vaginal cultures that are positive for N. meningitidis.