The escalating number of injuries and fatalities among cyclists is a pressing safety concern. In the United States, communities are actively seeking strategies to boost cyclist safety, with some states implementing bike-specific policies, such as stop-as-yield laws, to support cyclists. Stop-as-yield laws allow cyclists to treat stop signs as yield signs. The laws are not yet widely implemented, and their potential safety impact is a subject of debate among transportation experts and advocates. This study investigates how stop-as-yield laws can positively or negatively affect safety and provides insights and guidelines for California policymakers and safety practitioners if the law passes in California. We collected cyclist data from five states that have enacted stop-as-yield laws—Idaho, Arkansas, Oregon, Washington and Delaware—and data from some of their contiguous states without such legislation. Using an observational before-after study with comparison groups at the state level, the research examined changes in cyclist crash frequencies after the laws were implemented. Additionally, a random-effects negative binomial regression model with panel data was employed to estimate a law’s overall impact. The results did not indicate a significant change in cyclist crashes among the states with stop-as-yield laws.