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Scholarly Works (1 results)

Article
Peer Reviewed

Large‐scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta)

Kanthaswamy, Sree;
Reader, Rachel;
Tarara, Ross;
Oslund, Karen;
Allen, Mark;
Ng, Jillian;
Grinberg, Chloe;
Hyde, Dallas;
Glenn, David Glenn;
Lerche, Nicholas

UC Davis Previously Published Works (2014)

Hypertrophic Cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass. Analyses of 108 rhesus macaque probands with pronounced HCM revealed a strong genetic predisposition to this disease. Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically and anatomically.

Cover page: Large‐scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta)