- Schaaf, Zachary A;
- Ning, Shu;
- Leslie, Amy R;
- Sharifi, Masuda;
- Gao, Richard Y;
- Maine, James P;
- Lou, Wei;
- Lombard, Alan P;
- Liu, Chengfei;
- Yu, Ai-Ming;
- Mitsiades, Nicholas;
- Gao, Allen C
Significance
Olaparib, a PARP inhibitor, is effective against various cancers, including prostate cancer. However, resistance to olaparib poses a significant challenge. This study uncovers that mitochondrial alterations and PINK1 gene overexpression contribute to this resistance in prostate cancer cells. Enhanced mitochondrial functionality and increased PINK1 expression in olaparib-resistant cells underscore the importance of targeting mitochondrial dynamics and PINK1 to develop more effective treatments for overcoming olaparib resistance in prostate cancer.