Characterization and control of matter by optical means is at the forefront of research both due to fundamental insights and technological promise. Theoretical modeling of periodically driven systems is a prerequisite to understanding and engineering nanoscale quantum devices for quantum technologies. Here, we develop a theory for transport and optical response of molecular junctions, open nonequilibrium quantum systems, under external periodic driving. Periodic driving is described using the Floquet theory combined with nonequilibrium Green's function description of the system. Light-matter interaction is modeled by employing the self-consistent Born approximation. A generic three-level model is utilized to illustrate the effect of the driving on optical and transport properties of junctions.