Transgender people face an uncertain legal climate, and efforts to include gender identity in policies have been met with both successes and failures. These policies are often developed in the legislative process, which directly involve public opinion. To date, there is only one study analyzing American public attitudes toward transgender people. This research gap makes it unclear whether people in general understand what transgender means and whether public support for transgender rights depends on understanding and knowing transgender people. Since the population of transgender people is estimated to be smaller than that of lesbian, gay, and bisexual people, examining whether and how having a friend or family member who is lesbian or gay relates to transgender rights is important to understand political coalitions and attitude change. This study examines public attitudes about transgender rights in the USA. It finds that as respondents report being more informed about transgender people they tend to have more supportive attitudes. Interpersonal contact with someone who is lesbian or gay also leads to a secondary transfer of positive attitudes. About half of the secondary transfer effect operates through a mechanism of attitude generalization: contact positively affects the opinions people have on gay rights that then broaden to affect attitudes on transgender rights. Demographic characteristics also indicate that predictors of transgender attitudes are similar to previous studies regarding attitudes toward lesbians, gay men, and bisexuals. Further survey efforts need to consider inquiring about transgender rights and attitudes, as this remains a research gap in need of scholarly understanding.