Conceptions of social disparities as natural and biologically-caused, known as “essentialist” conceptions, support the maintenance of social disparities. Surprisingly little research has examined whether formal educational experiences – directly teaching people about the nature and origins of social disparities – can reduce essentialist conceptions. We investigate how social science coursework (e.g., sociology, history, anthropology) impacts (a) essentialist vs. structural explanations for racial disparities, and (b) social essentialism more broadly, in a diverse group of undergraduates (n = 246). Results suggest that students who have completed such coursework show reduced endorsement of essentialist explanations for racial disparities, but enhanced endorsement of other dimensions of social essentialist thought (e.g., the view that social categories are meaningfully distinct from one another). Thus, social science coursework may have a nuanced impact on social essentialism. We discuss the questions these results raise regarding the relations between explanatory thinking and other dimensions of social essentialism.