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Open Access Publications from the University of California

Scholarly Works (10 results)

  • Article
Fish Bulletin (1930)

This report is presented to aid directly the administrators of the Division of Fish and Game in their conservation program. Herein is given an account of the California halibut fishery and a detailed analysis of the catch in the Los Angeles Harbor district by means of the catch per unit of effort expended. The paper is so arranged that the general and fundamental aspects of the fishery and the results of a catch analysis are briefly given in the first part. For those who may be interested in the details of the fishery some of its life history and methods of boat catch analysis employed, the balance of the paper will be of importance.

    Cover page: Fish Bulletin No. 32. The California Halibut (Paralichthys californicus) and an Analysis of the Boat Catches
    • Article
    Fish Bulletin (1932)

    Fluctuations in the available supply of striped bass in the San Francisco Bay and Sacramento-San Joaquin river regions for the years 1920–1927 were shown in a bulletin (by Craig, 1930) published by the California Division of Fish and Game. The present report is a continuation of that study of the striped bass, which covers the period January 1, 1928 to August 14, 1931.

      Cover page: Fish Bulletin No. 39. Fluctuations in the Abundance of Striped Bass (Roccus lineatus) in California
      • Article
      Fish Bulletin (1929)

      This investigation under the authority of the Bureau of Commercial Fisheries, Division of Fish and Game of California, was started in the fall of 1927. The paper, while all on the general subject of Sacramento salmon, is in three parts, each of which is a separate problem. The first part, "Historical and Statistical Review of the Sacramento-San Joaquin Salmon Fishery," takes into consideration the early investigations, history, and statistics of the fishery, artificial propagation, legislation, water supply, prices, and the causes of depletion, with suggested remedies. The second problem, "Survey of Salmon Spawning Grounds in the Sacramento-San Joaquin River Systems," shows the available salmon spawning grounds in the systems as contrasted with the extent of the grounds in the early days. Each stream in the systems is taken up individually to show runs, spawning time and beds, obstructions to the fish, and abundance. The last part is on the "Determination of the Age of Maturity of the Sacramento-San Joaquin Salmon (Oncorhynchus tschawytscha)," and deals with the methods of age determination, the age of maturity, and age classes in relation to sex and types.

        Cover page: Fish Bulletin No. 17. Sacramento-San Joaquin Salmon (Oncorhynchus tschawytscha) Fishery of California
        • Article
        • Peer Reviewed
        Proceedings of the Annual Meeting of the Cognitive Science Society, Volume 19 (1997)
          Cover page: The Emotional Valence of Lexical Stimuli Affects Low-Level Visual Processing: Evidence From Backward Masking
          • Article
          • Peer Reviewed
          UC San Diego Previously Published Works (2018)
          Fusion proteins resulting from chromosomal translocations have been identified as oncogenic drivers in many cancers, allowing them to serve as potential drug targets in clinical practice. The genes encoding FGFRs, Fibroblast Growth Factor Receptors, are commonly involved in such translocations, with the FGFR3-TACC3 fusion protein frequently identified in many cancers, including glioblastoma, cervical cancer, bladder cancer, nasopharyngeal carcinoma, and lung adenocarcinoma among others. FGFR3-TACC3 retains the entire extracellular domain and most of the kinase domain of FGFR3, with its C-terminal domain fused to TACC3. We examine here the effects of targeting FGFR3-TACC3 to different subcellular localizations by appending either a nuclear localization signal (NLS) or a myristylation signal, or by deletion of the normal signal sequence. We demonstrate that the oncogenic effects of FGFR3-TACC3 require either entrance to the secretory pathway or plasma membrane localization, leading to overactivation of canonical MAPK/ERK pathways. We also examined the effects of different translocation breakpoints in FGFR3-TACC3, comparing fusion at TACC3 exon 11 with fusion at exon 8. Transformation resulting from FGFR3-TACC3 was not affected by association with the canonical TACC3-interacting proteins Aurora-A, clathrin, and ch-TOG. We have shown that kinase inhibitors for MEK (Trametinib) and FGFR (BGJ398) are effective in blocking cell transformation and MAPK pathway upregulation. The development of personalized medicines will be essential in treating patients who harbor oncogenic drivers such as FGFR3-TACC3.
            Cover page: Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling
            • Article
            • Peer Reviewed
            IDAV Publications (2001)
            We describe algorithms for automating the process of picking seismic events in prestack migrated common depth image gathers. The approach uses supervised learning and statistical classification algorithms along with advanced signal/image processing algorithms. No model assumption is made such as hyperbolic moveout. We train a probabilistic neural network for voxel classification using event times, subsurface points and offsets (ground truth information) picked manually by expert interpreters. The key to success is using effective features that capture the important behavior of the measured signals. We test a variety of features calculated in a local neighborhood about the voxel under analysis. Feature selection algorithms are used to ensure that we use only the features that maximize class separability. This event picking algorithm has the potential to reduce significantly the cycle time and cost of 3D prestack depth migration, while making the velocity model inversion more robust.
              Cover page: Automatic Event Picking in Prestack Migrated Gathers Using a Probabilistic Neural Network
              • Article
              • Peer Reviewed
              UC San Diego Previously Published Works (2023)
              FGFR3-TACC3 represents an oncogenic fusion protein frequently identified in glioblastoma, lung cancer, bladder cancer, oral cancer, head and neck squamous cell carcinoma, gallbladder cancer, and cervical cancer. Various exon breakpoints of FGFR3-TACC3 have been identified in cancers; these were analyzed to determine the minimum contribution of TACC3 for activation of the FGFR3-TACC3 fusion protein. While TACC3 exons 11 and 12 are dispensable for activity, our results show that FGFR3-TACC3 requires exons 13-16 for biological activity. A detailed analysis of exon 13, which consists of 8 heptads forming a coiled coil, further defined the minimal region for biological activity as consisting of 5 heptads from exon 13, in addition to exons 14-16. These conclusions were supported by transformation assays of biological activity, examination of MAPK pathway activation, analysis of disulfide-bonded FGFR3-TACC3, and by examination of the Endoglycosidase H-resistant portion of FGFR3-TACC3. These results demonstrate that clinically identified FGFR3-TACC3 fusion proteins differ in their biological activity, depending upon the specific breakpoint. This study further suggests the TACC3 dimerization domain of FGFR3-TACC3 as a novel target in treating FGFR translocation driven cancers.
                Cover page: Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability
                • Article
                • Peer Reviewed
                UC San Diego Previously Published Works (2021)
                We describe an individual in whom clinical and radiographic features are typical for achondroplasia, but in whom the common variants of FGFR3 that result in achondroplasia are absent. Whole exome sequencing demonstrated a novel, de novo 6 base pair tandem duplication in FGFR3 that results in the insertion of Ser-Phe after position Leu324. in vitro studies showed that this variant results in aberrant dimerization, excessive spontaneous phosphorylation of FGFR3 dimers and excessive, ligand-independent tyrosine kinase activity. Together, these data suggest that this variant leads to constitutive disulfide bond-mediated dimerization, and that this, surprisingly, occurs to an extent similar to the neonatal lethal thanatophoric dysplasia type I Ser249Cys variant.
                  Cover page: Typical achondroplasia secondary to a unique insertional variant of FGFR3 with in vitro demonstration of its effect on FGFR3 function
                  • Article
                  • Peer Reviewed
                  UCLA Previously Published Works (2022)

                  Background

                  Extracorporeal membrane oxygenation (ECMO) use in the United States occurs often in cardiothoracic ICUs (CTICU). It is unknown how it varies across ICU types.

                  Methods

                  We identified 10 893 ECMO runs from the Extracorporeal Life Support Organization (ELSO) Registry across 2018 and 2019. Primary outcome was ECMO case volume by ICU type (CTICU vs. non-CTICU). Adjusting for pre-ECMO characteristics and case mix, secondary outcomes were on-ECMO physiologic variables by ICU location stratified by support type.

                  Results

                  CTICU ECMO occurred in 65.1% and 55.1% (2018 and 2019) of total runs. A minority of total runs related to cardiac surgery procedures (CTICU: 21.7% [2018], 18% [2019]; non-CTICU: 11.2% [2018], 13% [2019]). After multivariate adjustment, non-CTICU ECMO for cardiac support associated with lower 4- and 24-h circuit flow (3.9 liters per minute [LPM] vs. 4.1 LPM, p < 0.0001; 4.1 LPM vs. 4.3 LPM, p < 0.0001); for respiratory support, lower on-ECMO mean fraction of inspired oxygen ([Fi O2 ], 67% vs. 69%, p = 0.02) and lower respiratory rate (14 vs. 15, p < 0.0001); and, for extracorporeal cardiopulmonary resuscitation (ECPR), lower ECMO flow rates at 24 h (3.5 LPM vs. 3.7 LPM, p = 0.01).

                  Conclusions

                  ECMO mostly remains in CTICUs though a minority is associated with cardiac surgery. Statistically significant but clinically minor differences in on-ECMO metrics were observed across ICU types.
                    Cover page: Similarities in extracorporeal membrane oxygenation management across intensive care unit types in the United States: An analysis of the Extracorporeal Life Support Organization Registry
                    • Article
                    • Peer Reviewed
                    UC San Francisco Previously Published Works (2012)
                    Background: Depression is associated with increased HIV transmission risk, increased morbidity, and higher risk of HIV-related death among HIV-infected women. Low sexual relationship power also contributes to HIV risk, but there is limited understanding of
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