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Open Access Publications from the University of California

Scholarly Works (2 results)

  • Thesis
  • Peer Reviewed
UCLA Electronic Theses and Dissertations (2020)

The transport of substances across the membrane and into the cell is essential for homeostasis. While biomolecules are intracellularly transported for essential functions of cellular growth and disposal, novel delivery vectors utilize the processes of endocytosis for therapy treatment, disease diagnosis, gene editing, and more. The use of fluorescent-based technologies to examine the kinetics of transported substances limits the quantification of the dynamic events occurring in endocytosis. Herein, the development of a tool to monitor the endocytic process in real-time using bioluminescent nanocapsules and quantification models is assessed. In the context of cervical cancer cells undergoing treatment, the platform introduces the potential of novel parameters in the development of optimal delivery vector design and in the development of drug treatments.

    Cover page: The Development of Real-time Endocytic Monitoring using Bioluminescent Nanocapsules and Quantification Models
    • Article
    • Peer Reviewed
    UC San Diego Previously Published Works (2016)
    Transient self-destroyed micromotors that autonomously disappear in biological media at controlled rates upon completing their task, without leaving a toxic residue, are presented. The propulsion and degradation characteristics of the self-destroyed Mg/ZnO, Mg/Si, and Zn/Fe Janus micromotors and single-component Zn micromotors are described. The degradation of the Janus micromotors relies on the different corrosion rates of their core-shell components. Inductively coupled plasma optical emission spectrometry measurements are used to probe the time-dependent degradation of the different constituents of the micromotors. The toxicity of the transient micromotors is discussed toward their potential use in biomedical applications. This concept of transient micromotors offers considerable potential for diverse practical applications in the near future.
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