The North American construction industry has seen substantial growth in the use of cold-formed steel (CFS) framing for midrise buildings in recent years. In seismic zones, CFS-framed buildings utilize shear walls to provide the primary lateral resistance to earthquake induced loads. Although oriented strand board (OSB) and plywood panels have been traditionally used as the sheathing material for these essential components, more recently, steel sheet sheathing has emerged as a novel strategy due to its strength, ductility, ease of installation, and use of noncombustible material, among other benefits. To address the paucity of data regarding CFS-framed shear wall response within actual wall lines of buildings, a two-phased experimental effort was conducted. Wall-line assemblies were fabricated and tested with shear walls placed in-line with gravity walls. The shear walls chord stud packs include tie-rod assemblies consistent with multi-story detailing. Specimens were either unfinished or finished, and the shear walls were laid out in a symmetrical or unsymmetrical fashion within in the wall line. In addition, both Type I and Type II shear wall and anchorage detailing were investigated. In this paper, the impact of test variables governing the structural detailing of CFS-framed walls are quantified through dynamic and quasi-static tests, and a companion paper presents findings regarding the impact of architectural variations on seismic performance.