- Ronen, Sabrina;
- Pieper, Russell;
- Phillips, Joanna;
- Izquierdo-Garcia, JL;
- Cai, LM;
- Chaumeil, MM;
- Eriksson, P;
- Robinson, AE;
- Pieper, RO;
- Phillips, JJ;
- Ronen, SM
Background: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert a-ketoglutarate to 2-hydroxyglutarate, ultimately leading to t