Unlike standard modal logics, many dynamic epistemic logics are not closed under uniform substitution. A distinction therefore arises between the logic and its substitution core, the set of formulas all of whose substitution instances are valid. The classic example of a non-uniform dynamic epistemic logic is Public Announcement Logic (PAL), and a well-known open problem is to axiomatize the substitution core of PAL. In this paper we solve this problem for PAL over the class of all relational models with infinitely many agents, PAL-K_omega, as well as standard extensions thereof, e.g., PAL-T_omega, PAL-S4_omega, and PAL-S5_omega. We introduce a new Uniform Public Announcement Logic (UPAL), prove completeness of a deductive system with respect to UPAL semantics, and show that this system axiomatizes the substitution core of PAL.